4.7 Article

Smart Design of Mitochondria-Targeted and ROS-Responsive CPI-613 Delivery Nanoplatform for Bioenergetic Pancreatic Cancer Therapy

Journal

NANOMATERIALS
Volume 11, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/nano11112875

Keywords

mitochondria-targeting; ROS-responsive; drug delivery; nanoparticles; pancreatic cancer therapy; CPI-613

Funding

  1. National Natural Science Foundation of China [21907012]
  2. Chongqing Natural Science Foundation [cstc2019jcyj-msxmX0766, cstc2020jcyj-msxmX0908]
  3. Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN201901341, KJQN201901329]
  4. Science & Technology Research Program of Chongqing University of Arts and Sciences [R2018SBX12, R2018SCH09]

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This study developed a novel mitochondria-targeted and ROS-triggered drug delivery nanoplatform for effective pancreatic cancer therapy, showing effective mitochondrial targeting, ROS-cleaving capability, and robust therapeutic performances.
Mitochondria, as the powerhouse of most cells, are not only responsible for the generation of adenosine triphosphate (ATP) but also play a decisive role in the regulation of apoptotic cell death, especially of cancer cells. Safe potential delivery systems which can achieve organelle-targeted therapy are urgently required. In this study, for effective pancreatic cancer therapy, a novel mitochondria-targeted and ROS-triggered drug delivery nanoplatform was developed from the TPP-TK-CPI-613 (TTCI) prodrug, in which the ROS-cleave thioketal functions as a linker connecting mitochondrial targeting ligand TPP and anti-mitochondrial metabolism agent CPI-613. DSPE-PEG2000 was added as an assistant component to increase accumulation in the tumor via the EPR effect. This new nanoplatform showed effective mitochondrial targeting, ROS-cleaving capability, and robust therapeutic performances. With active mitochondrial targeting, the formulated nanoparticles (TTCI NPs) demonstrate much higher accumulation in mitochondria, facilitating the targeted delivery of CPI-613 to its acting site. The results of in vitro antitumor activity and cell apoptosis revealed that the IC50 values of TTCI NPs in three types of pancreatic cancer cells were around 20~30 mu M, which was far lower than those of CPI-613 (200 mu M); 50 mu M TTCI NPs showed an increase in apoptosis of up to 97.3% in BxPC3 cells. Therefore, this mitochondria-targeted prodrug nanoparticle platform provides a potential strategy for developing safe, targeting and efficient drug delivery systems for pancreatic cancer therapy.

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