Journal
NANOMATERIALS
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/nano12020275
Keywords
stratum corneum; skin disorders; ceramides; glucocorticoids; nanoparticles; atopic dermatitis; psoriasis; xerosis; ichthyosis
Categories
Funding
- national funds through FCT-Foundation for Science and Technology, I.P. [EXPL/BTM-MAT/0112/2021, UIDB/04567/2020, UIDP/04567/2020, UI/BD/151423/2021]
- Fundação para a Ciência e a Tecnologia [EXPL/BTM-MAT/0112/2021, UI/BD/151423/2021] Funding Source: FCT
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This review highlights the important role of ceramides in the stratum corneum and the barrier dysfunction in skin diseases. It emphasizes the potential value of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment.
The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier with altered ceramide levels and increased loss of transepidermal water. Glucocorticoids are normally employed in the therapeutical management of these pathologies. However, they have shown a poor safety profile and reduced treatment efficiency. The main objective of this review is to, within the framework of the limitations of the currently available therapeutical approaches, establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment.
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