Journal
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
Volume 22, Issue 1, Pages 52-58Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10147-016-1034-5
Keywords
Head and neck cancer; [F-18]-FDG; PET/CT; Simulation; Intensity-modulated radiotherapy (IMRT); Marginal recurrence
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Funding
- Japan Society for the Promotion of Science [25461932, 16K10406]
- Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and Development, AMED [15ck0106093h0002]
- Grants-in-Aid for Scientific Research [16K10406, 26461892, 25461932, 25461854] Funding Source: KAKEN
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Background Clinical results of computed tomography (CT) simulations and [F-18]-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT simulations were compared retrospectively. Materials and methods Between 2006 and 2011, [F-18]FDG PET/CT simulation was performed on 68 consecutive patients with pharyngeal cancers (PET/CT group). As an historical control, conventional CT simulation was performed on 56 consecutive patients with pharyngeal cancer between 2000 and 2006 (CT group). In the PET/CT group, the primary sites were nasopharynx (NPC), oropharynx (OPC), and hypopharynx (HPC) in 35, 20, and 13 patients, respectively; in the CT group, the primary sites were NPC, OPC, and HPC in 21, 17, and 18 patients, respectively. All but five patients in the PET/CT group were treated with intensity modulated radiation therapy (IMRT). Results In the PET/CT group, TNM and clinical stages changed in 11 (16 %) and eight (12 %) patients, respectively. Although the 5-year overall survival (OS) rates for the PET/CT and the CT groups were 80 and 64 %,respectively (p = 0.0420), this result may be attributable to the background difference between the two groups. Similarly, the 5-year locoregional control rates of the two groups were 82 and 70 %, respectively (p = 0.0501). Notably, marginal recurrences around the planning target volume (PTV) were only noted in four CT group patients. Conclusion PET/CT simulation was useful for delineating an accurate clinical target volume (CTV) of pharyngeal cancer, and its clinical results were satisfactory.
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