Journal
NANOMATERIALS
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nano11113154
Keywords
anticancer activity; L-histidine; silver nanoparticles; cervical cancer cells; apoptosis
Categories
Funding
- Science and Engineering Research Board
- Indian Council of Medical Research, New Delhi, India
- SERBOverseas Visiting Doctoral Fellowship [ODF/2018/001044, 2017-2853/SCRT-BMS]
- University Grants Commission, New Delhi, India [F.18-1/2011(BSR)]
- Policy (TNMulti-Gen)
- European Union [739593]
- EU Program [H2020-EU.4]
- Hungarian National Research, Development and Innovation Office [2020-4.1.1-TKP2020]
- Data Science and AI Research (DSAIR) Centre of NTU [ADH-11/2017-DSAIR]
- Cognitive NeuroImaging Centre (CONIC) at NTU
- Lee Kong Chian School of Medicine and Nanyang Technological University, Singapore
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This study synthesized silver nanoparticles using L-histidine and characterized them through spectroscopic and microscopic studies. The results showed that the nanoparticles have potential in inhibiting cervical cancer cells, making them promising candidates for cervical cancer therapy.
This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 & PLUSMN; 19.83 nm and zeta potential of -20.5 & PLUSMN; 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC50 value of 18.25 & PLUSMN; 0.36 mu g/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.
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