Journal
MOLECULAR THERAPY-NUCLEIC ACIDS
Volume 26, Issue -, Pages 1130-1147Publisher
CELL PRESS
DOI: 10.1016/j.omtn.2021.10.017
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Funding
- National Natural Science Foundation of China [81900645, 82170779]
- Yellow Crane Talents Outstanding Youth Foundation of Wuhan
- Outstanding Youth Foundation of Tongji Hospital [2020YQ15]
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circRNAs play important regulatory roles in PCa, being closely associated with the biological behaviors and clinicopathological features of tumors, and may serve as potential diagnostic, prognostic, and therapeutic targets for PCa.
Circular RNAs (circRNAs) are covalently closed RNA molecules that play important regulatory roles in various tumors. Prostate cancer (PCa) is one of the most common malignant tumors in the world, with high morbidity and mortality. In recent years, more and more circRNAs have been found to be abnormally expressed and involved in the occurrence and development of PCa, including cell proliferation, apoptosis, invasion, migration, metastasis, chemotherapy resistance, and radiotherapy resistance. Most of the circRNAs regulate biological behaviors of cancer through a competitive endogenous RNA (ceRNA) regulatory mechanism, and some can exert their functions by binding to proteins. circRNAs are also associated with many clinicopathological features of PCa, including tumor grade, lymph node metastasis, and distant metastasis. In addition, circRNAs are potential diagnostic and prognostic biomarkers for PCa. Considering their critical regulatory roles in the progression of PCa, circRNAs would be the potential therapeutic targets. In this paper, the current research status of circRNAs in PCa is briefly reviewed.
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