4.6 Article

Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance

Related references

Note: Only part of the references are listed.
Article Oncology

RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

Qunsong Tan et al.

Summary: The study demonstrates that RNF8 ubiquitinates RecQL4 protein, facilitating its dissociation from DSB sites and hindering the recruitment of downstream DSB repair proteins. RecQL4 also interacts with WRAP53 beta, which enhances its association with RNF8. Overall, the ubiquitination event mediated by RNF8 is essential for RecQL4's function in DSB repair.

ONCOGENESIS (2021)

Review Cell Biology

Human RecQL4 as a Novel Molecular Target for Cancer Therapy

Adayabalam S. Balajee

Summary: Human RecQ helicases, especially RecQL4, play crucial roles in maintaining genomic stability and are associated with various syndromes and cancer susceptibility. RecQL4 mutations have been linked to several syndromes and increased cancer risk, making it a potential novel cancer therapeutic target.

CYTOGENETIC AND GENOME RESEARCH (2021)

Article Multidisciplinary Sciences

Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Yuina Sonohara et al.

SCIENTIFIC REPORTS (2019)

Article Genetics & Heredity

Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1

Norbert F. Ajeawung et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2019)

Article Genetics & Heredity

Mosaic Analysis in Drosophila

Federico Germani et al.

GENETICS (2018)

Article Biochemistry & Molecular Biology

Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome

Elisa A. Colombo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Genetics & Heredity

Mosaic Analysis in Drosophila

Federico Germani et al.

GENETICS (2018)

Article Biochemistry & Molecular Biology

The Saccharomyces cerevisiae Hrq1 and Pif1 DNA helicases synergistically modulate telomerase activity in vitro

David G. Nickens et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

DNA Polymerase Beta Participates in Mitochondrial DNA Repair

P. Sykora et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase

Cody M. Rogers et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Developmental Biology

Xenopus egg extract: A powerful tool to study genome maintenance mechanisms

Wouter S. Hoogenboom et al.

DEVELOPMENTAL BIOLOGY (2017)

Article Oncology

RECQL4 helicase has oncogenic potential in sporadic breast cancers

Arvind Arora et al.

JOURNAL OF PATHOLOGY (2016)

Review Cell Biology

The Fanconi anaemia pathway: newyplayers and new functions

Raphael Ceccaldi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Cell Biology

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

Huiming Lu et al.

CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Brendan A. I. Payne et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Article Biochemistry & Molecular Biology

The role of mitochondrial dysfunction in age-related diseases

Rebecca K. Lane et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Article Biochemical Research Methods

IBS: an illustrator for the presentation and visualization of biological sequences

Wenzhong Liu et al.

BIOINFORMATICS (2015)

Review Biochemistry & Molecular Biology

Human RecQ Helicases in DNA Repair, Recombination, and Replication

Deborah L. Croteau et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)

Review Biochemistry & Molecular Biology

The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival

Inmaculada Martinez-Reyes et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2014)

Article Multidisciplinary Sciences

Genetic Alterations of Chromosome 8 Genes in Oral Cancer

Zachary Wei Ern Yong et al.

SCIENTIFIC REPORTS (2014)

Review Multidisciplinary Sciences

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

Molly C. Kottemann et al.

NATURE (2013)

Article Multidisciplinary Sciences

RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis

Hongbo Fang et al.

PLOS ONE (2013)

Article Cell Biology

Nucleotide Excision Repair in Eukaryotes

Orlando D. Schaerer

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Cell Biology

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

Deborah L. Croteau et al.

AGING CELL (2012)

Article Biochemistry & Molecular Biology

RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair

Zhenfen Chi et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

Avik K. Ghosh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability

Dharmendra Kumar Singh et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Health Care Sciences & Services

Efflux Pump-Mediated Resistance in Chemotherapy

P. O. Ughachukwu et al.

ANNALS OF MEDICAL AND HEALTH SCIENCES RESEARCH (2012)

Article Chemistry, Analytical

Quantitative Determination of Acetaldehyde in Foods Using Automated Digestion with Simulated Gastric Fluid Followed by Headspace Gas Chromatography

Michael Uebelacker et al.

JOURNAL OF AUTOMATED METHODS & MANAGEMENT IN CHEMISTRY (2011)

Article Multidisciplinary Sciences

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

Frederic Langevin et al.

NATURE (2011)

Review Oncology

DNA interstrand crosslink repair and cancer

Andrew J. Deans et al.

NATURE REVIEWS CANCER (2011)

Article Cell Biology

The involvement of human RECQL4 in DNA double-strand break repair

Dharmendra Kumar Singh et al.

AGING CELL (2010)

Review Genetics & Heredity

The RecQ DNA Helicases in DNA Repair

Kara A. Bernstein et al.

ANNUAL REVIEW OF GENETICS, VOL 44 (2010)

Article Oncology

Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis

Yanrong Su et al.

CANCER RESEARCH (2010)

Article Genetics & Heredity

Rothmund-Thomson syndrome in siblings: evidence for acquired in vivo mosaicism

Noralane M. Lindor et al.

CLINICAL GENETICS (2010)

Review Genetics & Heredity

Rothmund-Thomson syndrome

Lidia Larizza et al.

ORPHANET JOURNAL OF RARE DISEASES (2010)

Review Genetics & Heredity

How the Fanconi Anemia Pathway Guards the Genome

George-Lucian Moldovan et al.

ANNUAL REVIEW OF GENETICS (2009)

Article Biochemistry & Molecular Biology

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

Xiaohua Xu et al.

EMBO JOURNAL (2009)

Article Biochemistry & Molecular Biology

Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4

Xiaohua Xu et al.

EMBO JOURNAL (2009)

Article Biochemistry & Molecular Biology

The mutation spectrum in RECQL4 diseases

H. Annika Siitonen et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2009)

Article Biochemistry & Molecular Biology

Direct and indirect roles of RECQL4 in modulating base excision repair capacity

Shepherd H. Schurman et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

Drosophila RecQ4 Has a 3′-5′ DNA Helicase Activity That Is Essential for Viability

Christopher Capp et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

Jun-Sub Im et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

RecQ helicases: multifunctional genome caretakers

Wai Kit Chu et al.

NATURE REVIEWS CANCER (2009)

Article Biology

In silico analyses of a new group of fungal and plant RecQ4-homologous proteins

Fernanda Barea et al.

COMPUTATIONAL BIOLOGY AND CHEMISTRY (2008)

Article Medicine, General & Internal

Mitochondrial dysfunction as a cause of ageing

A. Trifunovic et al.

JOURNAL OF INTERNAL MEDICINE (2008)

Review Biochemistry & Molecular Biology

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

Vilhelm A. Bohr

TRENDS IN BIOCHEMICAL SCIENCES (2008)

Article Biochemistry & Molecular Biology

Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts

Yuji Kumata et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Molecular genetics of RecQ helicase disorders

K. Hanada et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Biochemistry & Molecular Biology

RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome

Sean R. Werner et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Oncology

Rothmund-Thomson syndrome and RECQL4 defect: Splitting and lumping

L Larizza et al.

CANCER LETTERS (2006)

Article Genetics & Heredity

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

S Chang et al.

NATURE GENETICS (2004)

Article Multidisciplinary Sciences

DNA replication of mitotic chromatin in Xenopus egg extracts

TA Prokhorova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Neurosciences

Mitochondrial formation of reactive oxygen species

JF Turrens

JOURNAL OF PHYSIOLOGY-LONDON (2003)

Article Biochemistry & Molecular Biology

Growth retardation and skin abnormalities of the Recq/4-deficient mouse

Y Hoki et al.

HUMAN MOLECULAR GENETICS (2003)

Article Genetics & Heredity

RNA processing defects of the helicase gene RECQL4 in a compound heterozygous Rothmund-Thomson patient

A Beghini et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2003)

Review Oncology

RecQ helicases: Caretakers of the genome

ID Hickson

NATURE REVIEWS CANCER (2003)

Article Biochemistry & Molecular Biology

Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases

HA Siitonen et al.

HUMAN MOLECULAR GENETICS (2003)

Article Genetics & Heredity

Another TWIST on Baller-Gerold syndrome

ML Seto et al.

AMERICAN JOURNAL OF MEDICAL GENETICS (2001)

Letter Genetics & Heredity

Overlap between Baller-Gerold and Rothmund-Thomson syndrome

A Mégarbané et al.

CLINICAL DYSMORPHOLOGY (2000)