4.6 Article

Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog

Journal

GENES
Volume 13, Issue 1, Pages -

Publisher

MDPI
DOI: 10.3390/genes13010102

Keywords

Sapsaree dogs; hair length; RSPO2; FGF5; Korean native dogs

Funding

  1. Cooperative Research Program of the Center for Companion Animal Research [PJ01456801]
  2. Rural Development Administration, Republic of Korea

Ask authors/readers for more resources

Genetic analysis of the hair-length of Sapsaree dogs revealed a dominant mode of inheritance for long hair. A causative mutation for hair length variations was identified as the previously reported 167 bp insertion in RSPO2 3' untranslated region. The study also found a selection signature on CFA13 in long-haired breeds.
Genetic analysis of the hair-length of Sapsaree dogs, a Korean native dog breed, showed a dominant mode of inheritance for long hair. Genome-Wide Association Study (GWAS) analysis and subsequent Mendelian segregation analysis revealed an association between OXR1, RSPO2, and PKHD1L1 on chromosome 13 (CFA13). We identified the previously reported 167 bp insertion in RSPO2 3' untranslated region as a causative mutation for hair length variations. The analysis of 118 dog breeds and wolves revealed the selection signature on CFA13 in long-haired breeds. Haplotype analysis showed the association of only a few specific haplotypes to the breeds carrying the 167 bp insertion. The genetic diversity in the neighboring region linked to the insertion was higher in Sapsarees than in other Asian and European dog breeds carrying the same variation, suggesting an older history of its insertion in the Sapsaree genome than in that of the other breeds analyzed in this study. Our results show that the RSPO2 3' UTR insertion is responsible for not only the furnishing phenotype but also determining the hair length of the entire body depending on the genetic background, suggesting an epistatic interaction between FGF5 and RSPO2 influencing the hair-length phenotype in dogs.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available