4.6 Article

Mitochondrial Strokes: Diagnostic Challenges and Chameleons

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS

Syuichi Tetsuka et al.

Summary: MELAS should be considered in the differential diagnosis of acute ischemic stroke due to similar onset patterns and neurological symptoms. Advances in neuroimaging have facilitated differentiation between stroke and MELAS. Potential preventive treatments for stroke-like episodes in MELAS include supplementation with L-arginine or taurine, while new gene therapies offer promise for future treatment options.

METABOLIC BRAIN DISEASE (2021)

Article Clinical Neurology

Epilepsy Associated With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes

Jiaai Li et al.

Summary: This study found that epilepsy was more common in male MELAS patients and was associated with a poor prognosis. Poor prognosis was linked to brain atrophy, status epilepticus, and the use of anti-seizure medications with high mitochondrial toxicity.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) Syndrome Frequency, Clinical Features, Imaging, Histopathologic, and Molecular Genetic Findings in a Third-level Health Care Center in Mexico

Javier A. Galnares-Olalde et al.

Summary: MELAS syndrome, a mitochondrial genetic disease, poses a diagnostic challenge for clinicians and often leads to delayed diagnosis. This study in Mexico retrospectively analyzed data of six patients diagnosed with MELAS syndrome, highlighting the importance of suspecting the syndrome in young patients with stroke of undetermined etiology and neurological features.

NEUROLOGIST (2021)

Article Clinical Neurology

Brain dysfunction and thyroid antibodies: autoimmune diagnosis and misdiagnosis

Cristina Valencia-Sanchez et al.

Summary: Hashimoto encephalopathy, characterized by sub-acute onset encephalopathy and elevated thyroid antibodies, was diagnosed in only a minority of patients referred with suspected cases. Most patients were found to have alternative non-immune-mediated diagnoses, highlighting the limitations of relying solely on thyroid antibodies in the evaluation of autoimmune encephalopathies.

BRAIN COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae

Michael Salsaa et al.

SCIENTIFIC REPORTS (2020)

Review Emergency Medicine

The frequency, characteristics and aetiology of stroke mimic presentations: a narrative review

Graham McClelland et al.

EUROPEAN JOURNAL OF EMERGENCY MEDICINE (2019)

Review Clinical Neurology

Review: Central nervous system involvement in mitochondrial disease

N. Z. Lax et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2017)

Article Biochemistry & Molecular Biology

Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome

Caterina Garone et al.

HUMAN MOLECULAR GENETICS (2017)

Review Obstetrics & Gynecology

Novel reproductive technologies to prevent mitochondrial disease

Lyndsey Craven et al.

HUMAN REPRODUCTION UPDATE (2017)

Article Multidisciplinary Sciences

A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease

Sanjeev Rajakulendran et al.

PLOS ONE (2016)

Article Biochemistry & Molecular Biology

Early onset cardiomyopathy associated with the mitochondrial tRNALeu(UUR) 3271T>C MELAS mutation

Giacomo Brisca et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Review Endocrinology & Metabolism

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

Ayman W. El-Hattab et al.

MOLECULAR GENETICS AND METABOLISM (2015)

Article Rehabilitation

The pooled incidence of post-stroke seizure in 102 008 patients

Safeng Zou et al.

TOPICS IN STROKE REHABILITATION (2015)

Letter Clinical Neurology

Led astray: MELAS initially misdiagnosed as herpes simplex encephalitis

Rubesh Gooriah et al.

ACTA NEUROLOGICA BELGICA (2015)

Article Clinical Neurology

Neuroimaging characteristics in mitochondrial encephalopathies associated with the m.3243A>G MTTL1 mutation

Henriette J. Tschampa et al.

JOURNAL OF NEUROLOGY (2013)

Article Biochemistry & Molecular Biology

MELAS: A nationwide prospective cohort study of 96 patients in Japan

Shuichi Yatsuga et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Article Endocrinology & Metabolism

Clinical features and heteroplasmy in blood, urine and saliva in 34 Dutch families carrying the m.3243A > G mutation

Paul de Laat et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2012)

Letter Cardiac & Cardiovascular Systems

Manifestations of the mitochondrial A3243G mutation

Josef Finsterer

INTERNATIONAL JOURNAL OF CARDIOLOGY (2009)

Article Clinical Neurology

Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters

Antonio Jose da Rocha et al.

JOURNAL OF NEUROIMAGING (2008)

Article Genetics & Heredity

Tissue specific distribution of the 3243A→G mtDNA mutation

A. L. Frederiksen et al.

JOURNAL OF MEDICAL GENETICS (2006)

Review Clinical Neurology

Pathogenesis of stroke-like episodes in MELAS: Analysis of neurovascular cellular mechanisms

T Iizuka et al.

CURRENT NEUROVASCULAR RESEARCH (2005)

Article Clinical Neurology

Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS?

C Oppenheim et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2000)