Journal
GENES
Volume 13, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/genes13020215
Keywords
chromatin; double strand break (DSB); chromatin dynamics; DNA damage response (DDR); genome integrity
Categories
Funding
- Agence Nationale pour la Recherche [ANR-17-CE11-0025]
- Institut National du Cancer (INCA) [PLBIOR21018HH]
- initiatives d'excellence [Idex ANR11-LABX-0071, IDEX-0005-]
- Fondation ARC pour la recherche sur le Cancer [PJA32020060002313, DOC20190508798]
- Peruvian Scholarship Convictive of Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica (CONCYTEC)
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Research has shown that chromatin mobility is affected by DNA damage. In the case of double-strand breaks, the mobility of chromatin at the break site is severely affected, while that of other chromosomes is affected to a lesser extent.
The primary functions of the eukaryotic nucleus as a site for the storage, retrieval, and replication of information require a highly dynamic chromatin organization, which can be affected by the presence of DNA damage. In response to double-strand breaks (DSBs), the mobility of chromatin at the break site is severely affected and, to a lesser extent, that of other chromosomes. The how and why of such movement has been widely studied over the last two decades, leading to different mechanistic models and proposed potential roles underlying both local and global mobility. Here, we review the state of the knowledge on current issues affecting chromatin mobility upon DSBs, and highlight its role as a crucial step in the DNA damage response (DDR).
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