Journal
GENES
Volume 13, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/genes13010034
Keywords
S; aureus; two-component systems; histidine kinase; signal sensing; ligand
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [EXC 2124]
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This review summarizes the current understanding of signal perception by histidine kinases in Staphylococcus aureus and their role in promoting appropriate gene expression in response to environmental challenges.
Staphylococcus aureus encodes 16 two-component systems (TCSs) that enable the bacteria to sense and respond to changing environmental conditions. Considering the function of these TCSs in bacterial survival and their potential role as drug targets, it is important to understand the exact mechanisms underlying signal perception. The differences between the sensing of appropriate signals and the transcriptional activation of the TCS system are often not well described, and the signaling mechanisms are only partially understood. Here, we review present insights into which signals are sensed by histidine kinases in S. aureus to promote appropriate gene expression in response to diverse environmental challenges.
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