4.6 Article

Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

Journal

FRONTIERS IN PHYSIOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.689807

Keywords

osseointegration; bioactive titanium; hypoxia; normoxia; osteoblast

Categories

Funding

  1. Natural Science Foundation of Guangdong Province [2016A030310240]
  2. Guangdong Science and Technology Innovation Strategy Special Fund Project [2018KJY2014]
  3. Medical Research Foundation of Guangdong Province [B2019117]
  4. Guangdong Provincial Administration of Traditional Chinese Medicine, Chinese Medicine Research Project [20202129]
  5. Natural Science Foundation of Tibet Autonomous Region [XZ2017ZR-ZYZ37]
  6. National Natural Science Foundation of China for Youth [81600900]

Ask authors/readers for more resources

The study found that a hypoxic environment and rough titanium implant surface promote osteogenic differentiation of osteoblasts and activate the JAK1/STAT1/HIF-1 alpha pathway in vitro. In animal studies, bone repair at high altitudes was slower than at low altitudes after 2 weeks, but bone formation did not differ significantly after 4 weeks. The results suggest that the altitude hypoxia environment affects the early osseointegration of titanium implants, with rough surfaces mitigating the effects.
Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1 alpha pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1 alpha pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available