4.6 Review

Periodontal Inflammation and Systemic Diseases: An Overview

Related references

Note: Only part of the references are listed.
Review Virology

The cytokine storm and COVID-19

Biying Hu et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Biochemistry & Molecular Biology

In-vivo imaging revealed antigen-directed gingival B10 infiltration in experimental periodontitis

Yufeng Wang et al.

Summary: Antigen specificity plays a crucial role in the local infiltration of B10 cells into periodontal tissue, promoting anti-inflammatory responses in experimental periodontitis.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Article Dentistry, Oral Surgery & Medicine

Competing interplay between systemic and periodontal inflammation: obesity overrides the impact of oral periphery

Peter Meisel et al.

Summary: This study investigated the interaction between local inflammation, periodontitis, and obesity, and found that probing depth and plaque were positively associated with C-reactive protein. Adjusting for waist circumference attenuated the association between probing depth and CRP, but did not eliminate it, with similar findings for plaque.

CLINICAL ORAL INVESTIGATIONS (2021)

Article Biochemistry & Molecular Biology

Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis

Simon Haworth et al.

Summary: Hypothesis-free Mendelian randomization studies and the LCV approach provide methods for causal inference across the human phenome. Automated pipeline for phenome-wide tests using LCV approach shows that lipids and BMI contribute to multiple traits and conditions, while dental caries and periodontitis are downstream consequences of other traits and diseases. Causal architecture plots based on partial genetic causality estimates offer a new way to visualize the overall causal map of the human phenome.

EUROPEAN JOURNAL OF HUMAN GENETICS (2021)

Article Dentistry, Oral Surgery & Medicine

The associations between major dietary patterns and risk of periodontitis

Ahmed A. Alhassani et al.

Summary: Overall, there was no significant association between Western or prudent dietary patterns and periodontitis. However, among obese individuals, the Western dietary pattern was significantly associated with higher risk of periodontitis.

JOURNAL OF CLINICAL PERIODONTOLOGY (2021)

Article Dentistry, Oral Surgery & Medicine

Periodontal Inflammation Primes the Systemic Innate Immune Response

N. Fine et al.

Summary: The presence of periodontal diseases is closely related to other chronic inflammatory conditions such as cardiovascular disease, diabetes, and arthritis. Studies show that periodontal tissue inflammation affects the production and activation of polymorphonuclear neutrophils (PMNs), contributing to a hyperinflammatory response in the body. This systemic effect of PD on immune response can exacerbate inflammatory reactions when faced with secondary infections, highlighting the complex interactions between PD and other inflammatory diseases.

JOURNAL OF DENTAL RESEARCH (2021)

Article Medicine, General & Internal

Is systemic inflammation a missing link between periodontitis and hypertension? Results from two large population-based surveys

E. Munoz Aguilera et al.

Summary: The study found a close relationship between periodontitis and hypertension, with systemic inflammation partially mediating this association.

JOURNAL OF INTERNAL MEDICINE (2021)

Article Geriatrics & Gerontology

Contribution ofPorphyromonas gingivalislipopolysaccharide to experimental periodontitis in relation to aging

Juliet Akkaoui et al.

Summary: Aging is associated with reduced TLR4 expression and attenuated response to Pg-LPS in osteoclast precursors, while Pg-LPS has little impact on promoting periodontitis in aged mice. The study suggests that periodontal disease in older mice may occur through mechanisms independent of the canonical signaling mediated by the Pg-LPS/TLR4 axis.

GEROSCIENCE (2021)

Review Dermatology

Oral manifestations of COVID-19 disease: A review article

Behzad Iranmanesh et al.

Summary: Dysgeusia is the first recognized oral symptom of COVID-19, and oral lesions in patients can manifest as various types including ulcers, vesicles, and pigmentation, with the most common sites being the tongue and labial mucosa. Older patients with severe COVID-19 are more likely to have widespread and severe oral lesions.

DERMATOLOGIC THERAPY (2021)

Letter Medicine, Research & Experimental

Periodontal pocket and COVID-19: Could there be a possible link?

Nirupa Elisetti

Summary: COVID-19 is an emerging health emergency that has devastated global economies and hindered individual well-being. Despite sustained research efforts, no definitive remedies for the virus have been found yet. Studies have shown consistent features specific to the disease, such as massive destruction of the lung, which disrupts the host's immune response.

MEDICAL HYPOTHESES (2021)

Review Dentistry, Oral Surgery & Medicine

Periodontal health and disease: The contribution of genetics

Luciana Macchion Shaddox et al.

Summary: Periodontitis is an infectious, inflammatory disease that is influenced by the interaction of specific bacteria, host response, and environmental factors. Genetic factors have been implicated in the pathogenesis of the disease, particularly for the more aggressive forms, due to its high degree of familial aggregation. This review provides an overview of the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.

PERIODONTOLOGY 2000 (2021)

Review Medicine, General & Internal

SARS-CoV-2 Infection and Oral Health: Therapeutic Opportunities and Challenges

Christopher J. Coke et al.

Summary: COVID-19 patients are more susceptible to oral health problems, with severe periodontal disease potentially worsening symptoms. Good periodontal health may help reduce the severity of infection, especially in patients with metabolic diseases. Dentistry professionals are at higher risk of exposure due to the use of aerosol-generating instruments.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Medicine, General & Internal

Severe COVID-19 Lung Infection in Older People and Periodontitis

Ruben Aquino-Martinez et al.

Summary: Periodontal bacteria dissemination into the lower respiratory tract may increase the risk of severe COVID-19 lung infection in older patients, as bacterial infection can cause permanent damage and senescence in cells, which in turn facilitates SARS-CoV-2 replication.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Dentistry, Oral Surgery & Medicine

Association between periodontitis and severity of COVID-19 infection: A case-control study

Nadya Marouf et al.

Summary: Periodontitis was found to be associated with an increased risk of COVID-19 complications, including death, ICU admission, and need for assisted ventilation. Additionally, COVID-19 patients with periodontitis had higher levels of white blood cells, D-dimer, and C Reactive Protein, which are biomarkers linked to worse disease outcomes.

JOURNAL OF CLINICAL PERIODONTOLOGY (2021)

Article Dentistry, Oral Surgery & Medicine

Investigation of Genetic Polymorphisms in BMP2, BMP4, SMAD6, and RUNX2 and Persistent Apical Periodontitis

Erika Calvano Kuchler et al.

Summary: This study discovered interactions between specific SNPs in the BMP2 and RUNX2 genes related to persistent apical periodontitis, suggesting that interplay between these SNPs increases the risk of developing PAP.

JOURNAL OF ENDODONTICS (2021)

Article Biochemistry & Molecular Biology

Runs of homozygosity are associated with staging of periodontitis in isolated populations

Massimo Mezzavilla et al.

Summary: The study revealed an association between long runs of homozygosity (ROH) and the severity of periodontitis, with a positive correlation between the amount of ROH and the staging of periodontitis. Regression tree analysis demonstrated the significant impact of ROH burden in discriminating individuals with different stages of periodontitis. Furthermore, ROH mapping highlighted the potential role of multiple genes in periodontal development.

HUMAN MOLECULAR GENETICS (2021)

Review Medicine, Research & Experimental

Nexus between COVID-19 and periodontal disease

Kanchana Sukumar et al.

Summary: Studies have shown a bi-directional relationship between periodontal disease and systemic conditions, with cytokines playing a key role in their associations. Bacterial exchange between the mouth and lungs may lead to the occurrence of periodontitis and pulmonary diseases.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

Article Dentistry, Oral Surgery & Medicine

Nitrate-rich diet alters the composition of the oral microbiota in periodontal recall patients

Yvonne Jockel-Schneider et al.

Summary: Periodontal recall patients consuming a nitrate-rich diet experienced a significant decrease in gingival inflammation, accompanied by significant changes in the subgingival microbiome composition.

JOURNAL OF PERIODONTOLOGY (2021)

Review Chemistry, Physical

The Influence of Diet on Oxidative Stress and Inflammation Induced by Bacterial Biofilms in the Human Oral Cavity

Ilona Rowinska et al.

Summary: The article provides a concise overview of the etiology of pathogenic microorganisms causing oral diseases, highlighting the role of diet and oxidative stress in periodontal diseases. The study suggests that a specific diet may be beneficial in preventing and treating periodontal diseases, offering innovative insights into the potential use of diet in oral hygiene prophylaxis against periodontitis.

MATERIALS (2021)

Article Nutrition & Dietetics

The Role of Inflammatory Diet and Vitamin D on the Link between Periodontitis and Cognitive Function: A Mediation Analysis in Older Adults

Joao Botelho et al.

Summary: Patients with periodontitis are at higher risk of cognitive dysfunction, with dietary inflammatory load and vitamin D deficiency potentially mediating this association. In a study involving over 2000 participants, it was found that both dietary inflammatory index and vitamin D levels played a role in the link between periodontitis and impaired cognitive function. Future research should further investigate these mediators in the connection between periodontitis and cognitive decline.

NUTRIENTS (2021)

Review Dentistry, Oral Surgery & Medicine

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

Jerian Gonzalez-Febles et al.

Summary: Rheumatoid arthritis and periodontitis are chronic inflammatory diseases characterized by the destruction of cartilage and periodontal tissues, with emerging evidence suggesting a possible link between specific bacterial periodontal pathogens and the development of autoantibodies in rheumatoid arthritis patients. Research is ongoing to explore the epidemiologic association and biological mechanisms between these two diseases, as well as the potential impact of periodontal treatment on the initiation and progression of rheumatoid arthritis.

PERIODONTOLOGY 2000 (2021)

Article Biochemistry & Molecular Biology

Changes in the Biomarkers of Oxidative/Nitrosative Stress and Endothelial Dysfunction Are Associated with Cardiovascular Risk in Periodontitis Patients

Nadia Ferlazzo et al.

Summary: This study found that patients with cardiovascular disease and periodontitis share common risk factors, with plasma biomarkers related to inflammatory status in these patients; certain gene expression levels in peripheral blood mononuclear cells were significantly up-regulated in patient groups. This suggests a possible link between oxidative stress, inflammasome activation, and endothelial dysfunction in periodontitis patients leading to the pathogenesis and progression of coronary heart disease.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2021)

Article Dentistry, Oral Surgery & Medicine

Periodontitis and alzheimer's disease

Daniel Sansores-Espana et al.

Summary: Alzheimer's disease and periodontitis share similar pathophysiological pathways with cellular and molecular proinflammatory characteristics. In periodontitis, locally produced cytokines and pro-inflammatory products can spread systemically or to the brain, potentially contributing to the development of Alzheimer's disease.

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL (2021)

Article Dentistry, Oral Surgery & Medicine

Systemic inflammatory impact of periodontitis on cognitive impairment

Jose Antonio Gil Montoya et al.

GERODONTOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Healthy diet reduces markers of cardiac injury and inflammation regardless of macronutrients: Results from the OmniHeart trial

Lara C. Kovell et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

Article Dentistry, Oral Surgery & Medicine

Identification of novel key lncRNAs involved in periodontitis by weighted gene co-expression network analysis

Su-Han Jin et al.

JOURNAL OF PERIODONTAL RESEARCH (2020)

Article Dentistry, Oral Surgery & Medicine

Association between periodontal inflammation and hypertension using periodontal inflamed surface area and bleeding on probing

Davide Pietropaoli et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2020)

Review Dentistry, Oral Surgery & Medicine

Periodontitis and respiratory diseases: A systematic review with meta-analysis

Isaac Suzart Gomes-Filho et al.

ORAL DISEASES (2020)

Review Microbiology

Exploring the putative interactions between chronic kidney disease and chronic periodontitis

Niall A. Hickey et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2020)

Article Dentistry, Oral Surgery & Medicine

Periodontitis and systemic markers of neurodegeneration: A case-control study

Yago Leira et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2020)

Article Dentistry, Oral Surgery & Medicine

Treatment of periodontitis reduces systemic inflammation in type 2 diabetes

Philip M. Preshaw et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2020)

Article Dentistry, Oral Surgery & Medicine

Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis

Carmen M. Diaz et al.

JOURNAL OF PERIODONTAL RESEARCH (2020)

Review Dentistry, Oral Surgery & Medicine

New developments in neutrophil biology and periodontitis

George Hajishengallis

PERIODONTOLOGY 2000 (2020)

Article Dentistry, Oral Surgery & Medicine

Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis

Francisco Wanderley Garcia Paula-Silva et al.

ARCHIVES OF ORAL BIOLOGY (2020)

Article

Inflammation, diet, and type 2 diabetes: a mini-review

Simin Jafaripour et al.

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2020)

Article Medicine, General & Internal

Knock-on effect of periodontitis to the pathogenesis of Alzheimer's disease?

Friedrich Leblhuber et al.

WIENER KLINISCHE WOCHENSCHRIFT (2020)

Article Dentistry, Oral Surgery & Medicine

Shifting the paradigm from inhibitors of inflammation to resolvers of inflammation in periodontitis

Thomas E. Van Dyke

JOURNAL OF PERIODONTOLOGY (2020)

Article Medicine, Research & Experimental

Periodontal pockets: A potential reservoir for SARS-CoV-2?

Zahi Badran et al.

MEDICAL HYPOTHESES (2020)

Letter Medicine, Research & Experimental

COVID-19 & Periodontitis: The cytokine connection

Vaibhav Sahni et al.

MEDICAL HYPOTHESES (2020)

Review Medicine, General & Internal

Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review

Gennaro Cecoro et al.

MEDICINA-LITHUANIA (2020)

Article Biochemistry & Molecular Biology

Is there an association between oral health and severity of COVID-19 complications?

Nathalie Botros et al.

BIOMEDICAL JOURNAL (2020)

Review Dentistry, Oral Surgery & Medicine

Periodontitis and rheumatoid arthritis: An update 2012-2017

Peter Mark Bartold et al.

PERIODONTOLOGY 2000 (2020)

Review Dentistry, Oral Surgery & Medicine

Periodontal disease and adverse pregnancy outcomes

Yiorgos A. Bobetsis et al.

PERIODONTOLOGY 2000 (2020)

Review Dentistry, Oral Surgery & Medicine

Mechanisms underlying the association between periodontitis and atherosclerotic disease

Harvey A. Schenkein et al.

PERIODONTOLOGY 2000 (2020)

Review Dentistry, Oral Surgery & Medicine

The role of inflammation and genetics in periodontal disease

Bruno G. Loos et al.

PERIODONTOLOGY 2000 (2020)

Review Dentistry, Oral Surgery & Medicine

The association of periodontal diseases with metabolic syndrome and obesity

Soren Jepsen et al.

PERIODONTOLOGY 2000 (2020)

Article Dentistry, Oral Surgery & Medicine

Citrullination in periodontium is associated with Porphyromonas gingivalis

Alejandra Maldonado et al.

ARCHIVES OF ORAL BIOLOGY (2020)

Review Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Yujun Tang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Nutrition & Dietetics

Association between diet and periodontitis: a cross-sectional study of 10,000 NHANES participants

David M Wright et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

Review Dentistry, Oral Surgery & Medicine

Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress

Wenjing Liu et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2020)

Review Oncology

Periodontitis and oral cancer - current concepts of the etiopathogenesis

Soussan Irani et al.

ONCOLOGY REVIEWS (2020)

Article Dentistry, Oral Surgery & Medicine

Increase in serum and salivary neutrophil gelatinise-associated lipocalin levels with increased periodontal inflammation

Aykut Tan et al.

JOURNAL OF APPLIED ORAL SCIENCE (2020)

Review Dentistry, Oral Surgery & Medicine

Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis

Mauricio Baeza et al.

JOURNAL OF APPLIED ORAL SCIENCE (2020)

Article Biochemistry & Molecular Biology

MMP-12 and S100s in saliva reflect different aspects of periodontal inflammation

Sofia Bjornfot Holmstrom et al.

CYTOKINE (2019)

Article Dentistry, Oral Surgery & Medicine

Chronic alcohol consumption increases inflammation and osteoclastogenesis in apical periodontitis

R. Dal-Fabbro et al.

INTERNATIONAL ENDODONTIC JOURNAL (2019)

Article Dentistry, Oral Surgery & Medicine

Inhibition of angiotensin II receptor I prevents inflammation and bone loss in periodontitis

Jinle Li et al.

JOURNAL OF PERIODONTOLOGY (2019)

Review Dentistry, Oral Surgery & Medicine

Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

N. Peddis et al.

AUSTRALIAN DENTAL JOURNAL (2019)

Article Mathematical & Computational Biology

Modeling the Effect of High Calorie Diet on the Interplay between Adipose Tissue, Inflammation, and Diabetes

V. Prana et al.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2019)

Article Dentistry, Oral Surgery & Medicine

Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

David Jonathan Rodrigues Gusman et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

Article Dentistry, Oral Surgery & Medicine

Association of Periodontitis with Oral Cancer: A Case-Control Study

Y. J. Shin et al.

JOURNAL OF DENTAL RESEARCH (2019)

Review Cell Biology

Contribution of Statins towards Periodontal Treatment: A Review

Catherine Petit et al.

MEDIATORS OF INFLAMMATION (2019)

Article Cell Biology

Apoptosis Transcriptional Profile Induced by Porphyromonas gingivalis HmuY

Paulo C. Carvalho-Filho et al.

MEDIATORS OF INFLAMMATION (2019)

Review Cell Biology

Chronic Inflammation as a Link between Periodontitis and Carcinogenesis

Anilei Hoare et al.

MEDIATORS OF INFLAMMATION (2019)

Article Genetics & Heredity

Detection of Exosomal PD-L1 RNA in Saliva of Patients With Periodontitis

Jialiang Yu et al.

FRONTIERS IN GENETICS (2019)

Review Biochemistry & Molecular Biology

Association between periodontal pathogens and systemic disease

Fiona Q. Bui et al.

BIOMEDICAL JOURNAL (2019)

Article Dentistry, Oral Surgery & Medicine

Epigenetic and inflammatory events in experimental periodontitis following systemic microbial challenge

Daniela B. Palioto et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

Article Dentistry, Oral Surgery & Medicine

Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis

Mehmet Murat Taskan et al.

JOURNAL OF PERIODONTAL RESEARCH (2019)

Review Cell Biology

Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?

Fulvia Ceccarelli et al.

MEDIATORS OF INFLAMMATION (2019)

Article Immunology

Systemic inflammation linking chronic periodontitis to cognitive decline

Rachel Pei-Hsuan Wang et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

Review Biochemistry & Molecular Biology

Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases

Kuebra Bunte et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Dentistry, Oral Surgery & Medicine

Protective roles of FICZ and aryl hydrocarbon receptor axis on alveolar bone loss and inflammation in experimental periodontitis

Jing Huang et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

Article Dentistry, Oral Surgery & Medicine

Severe periodontitis may influence cementum and dental pulp through inflammation, oxidative stress, and apoptosis

Xiangchun Li et al.

JOURNAL OF PERIODONTOLOGY (2019)

Article Dentistry, Oral Surgery & Medicine

Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial-mesenchymal transition in mice

Jin Sook Suh et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2019)

Article Multidisciplinary Sciences

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Dmitry Shungin et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

Lu Jia et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Review Immunology

Distal Consequences of Oral Inflammation

Joanne E. Konkel et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Medicine, General & Internal

Saliva and Serum Immune Responses in Apical Periodontitis

Milla Pietiainen et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Medicine, General & Internal

Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues

Eija Kononen et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Dentistry, Oral Surgery & Medicine

Host modulation therapy using anti-inflammatory and antioxidant agents in periodontitis: A review to a clinical translation

Benso Sulijaya et al.

ARCHIVES OF ORAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions

Rafael Scaf de Molon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Endocrinology & Metabolism

An investigation of the bidirectional link between osteoporosis and periodontitis

D. C. Penoni et al.

ARCHIVES OF OSTEOPOROSIS (2019)

Review Medicine, General & Internal

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

Eduardo Gomez-Banuelos et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Endocrinology & Metabolism

Oral microbiota-induced periodontitis: a new risk factor of metabolic diseases

Matthieu Minty et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2019)

Review Dentistry, Oral Surgery & Medicine

The cytokine network involved in the host immune response to periodontitis

Weiyi Pan et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2019)

Editorial Material Nutrition & Dietetics

A Traditional Mediterranean Diet Effectively Reduces Inflammation and Improves Cardiovascular Health

Cristina Razquin et al.

NUTRIENTS (2019)

Article Immunology

Host-Microbial Interactions in Systemic Lupus Erythematosus and Periodontitis

Larissa Pessoa et al.

FRONTIERS IN IMMUNOLOGY (2019)

Editorial Material Dentistry, Oral Surgery & Medicine

An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis

Peter Mark Bartold et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

Review Cell Biology

Macrophage immunomodulation in chronic osteolytic diseases-the case of periodontitis

Corneliu Sima et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Article Endocrinology & Metabolism

The influence of diabetes and or periodontitis on inflammation and adiponectin level

Dyah Purnamasari et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

Review Gastroenterology & Hepatology

Role of diet and gut microbiota on colorectal cancer immunomodulation

Carolina Vieira De Almeida et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Review Endocrinology & Metabolism

The relationship of diabetes, periodontitis and cardiovascular disease

Anandhara Indriani Khumaedi et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

Article Nutrition & Dietetics

Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease

Andrea M. McGrattan et al.

CURRENT NUTRITION REPORTS (2019)

Article Dentistry, Oral Surgery & Medicine

Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid?

Alkisti Zekeridou et al.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2019)

Review Respiratory System

Review of the association between periodontitis and chronic obstructive pulmonary disease in smokers

Agathi Spiropoulou et al.

MONALDI ARCHIVES FOR CHEST DISEASE (2019)

Review Dentistry, Oral Surgery & Medicine

Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis

Sivge Kurgan et al.

PERIODONTOLOGY 2000 (2018)

Review Medicine, General & Internal

Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases

Elsa Maria Cardoso et al.

POSTGRADUATE MEDICINE (2018)

Article Biochemistry & Molecular Biology

The extent of pyroptosis varies in different stages of apical periodontitis

Ran Cheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Nutrition & Dietetics

Diet-borne systemic inflammation is associated with prevalent tooth loss

Georgios A. Kotsakis et al.

CLINICAL NUTRITION (2018)

Review Cardiac & Cardiovascular Systems

Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease

Edgar Francisco Carrizales-Sepulveda et al.

HEART LUNG AND CIRCULATION (2018)

Review Biochemistry & Molecular Biology

Mesenchymal Stem Cells of Dental Origin for Inducing Tissue Regeneration in Periodontitis: A Mini-Review

Beatriz Hernandez-Monjaraz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Dentistry, Oral Surgery & Medicine

Pro-inflammatory and anti-inflammatory cytokine expression in post-treatment apical periodontitis

Nilton Dessaune Neto et al.

JOURNAL OF APPLIED ORAL SCIENCE (2018)

Article Biotechnology & Applied Microbiology

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Haebom Kim et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2018)

Article Dentistry, Oral Surgery & Medicine

Effects of colchicine on gingival inflammation, apoptosis, and alveolar bone loss in experimental periodontitis

Cuneyt Asim Aral et al.

JOURNAL OF PERIODONTOLOGY (2018)

Article Oncology

Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study

Dominique S. Michaud et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Dentistry, Oral Surgery & Medicine

SOD2 is upregulated in periodontitis to reduce further inflammation progression

Yong Yoon et al.

ORAL DISEASES (2018)

Article Multidisciplinary Sciences

Is periodontitis a risk indicator for cancer? A meta-analysis

Stefano Corbella et al.

PLOS ONE (2018)

Article Dentistry, Oral Surgery & Medicine

Periodontitis in patients with cirrhosis: a cross-sectional study

Lea Ladegaard Gronkjaer et al.

BMC ORAL HEALTH (2018)

Article Oncology

Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study

Dominique S. Michaud et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Review Neurosciences

Implications of Systemic Inflammation and Periodontitis for Major Depression

Sadayuki Hashioka et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Microbiology

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Talita Gomes Baeta Lourenco et al.

JOURNAL OF ORAL MICROBIOLOGY (2018)

Review Dentistry, Oral Surgery & Medicine

Genetics of periodontitis: Discovery, biology, and clinical impact

Arne S. Schaefer

PERIODONTOLOGY 2000 (2018)

Review Immunology

Reassessing the Role of Entamoeba gingivalis in Periodontitis

Mark Bonner et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)

Review Dentistry, Oral Surgery & Medicine

Regulation of defensive function on gingival epithelial cells can prevent periodontal disease

Tsuyoshi Fujita et al.

JAPANESE DENTAL SCIENCE REVIEW (2018)

Review Dentistry, Oral Surgery & Medicine

Periodontal disease and the metabolic syndrome

Ira B. Lamster et al.

INTERNATIONAL DENTAL JOURNAL (2017)

Review Dentistry, Oral Surgery & Medicine

The role of Toll-like receptors in periodontitis

B. Song et al.

ORAL DISEASES (2017)

Article Public, Environmental & Occupational Health

Periodontal Disease, Tooth Loss, and Cancer Risk

Dominique S. Michaud et al.

EPIDEMIOLOGIC REVIEWS (2017)

Review Genetics & Heredity

Interluekin-17A (IL17A)

Kong Chen et al.

Review Biochemistry & Molecular Biology

Matrix Metalloproteinases as Regulators of Periodontal Inflammation

Cavalla Franco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Dentistry, Oral Surgery & Medicine

NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation

D. Kim et al.

JOURNAL OF DENTAL RESEARCH (2017)

Review Dentistry, Oral Surgery & Medicine

Genetic Susceptibility Contributing to Periodontal and Cardiovascular Disease

G. Aarabi et al.

JOURNAL OF DENTAL RESEARCH (2017)

Article Dentistry, Oral Surgery & Medicine

Prevalence of Apical Periodontitis in Patients with Inflammatory Bowel Diseases: A Retrospective Clinical Study

Vanessa Piras et al.

JOURNAL OF ENDODONTICS (2017)

Article Dentistry, Oral Surgery & Medicine

Patients with chronic periodontitis present increased risk for osteoporosis: A population-based cohort study in Taiwan

L. -P. Mau et al.

JOURNAL OF PERIODONTAL RESEARCH (2017)

Article Dentistry, Oral Surgery & Medicine

Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study

D. Listyarifah et al.

ORAL DISEASES (2017)

Review Dentistry, Oral Surgery & Medicine

Host modulation: controlling the inflammation to control the infection

P. Mark Bartold et al.

PERIODONTOLOGY 2000 (2017)

Review Biochemical Research Methods

Contribution of proteomics to our understanding of periodontal inflammation

Nagihan Bostanci et al.

PROTEOMICS (2017)

Review Geriatrics & Gerontology

Periodontitis and Alzheimer's Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation

Francisco B. Teixeira et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Article Oncology

Epigenetic regulation of inflammation in localized aggressive periodontitis

L. M. Shaddox et al.

CLINICAL EPIGENETICS (2017)

Article Dentistry, Oral Surgery & Medicine

Anti-inflammatory effect of rosuvastatin decreases alveolar bone loss in experimental periodontitis

Fatma Y. Kirzioglu et al.

JOURNAL OF ORAL SCIENCE (2017)

Review Immunology

Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1

Maria G. Balta et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Medicine, General & Internal

Periodontal diseases

Denis F. Kinane et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Dentistry, Oral Surgery & Medicine

Resistin as potential biomarker for chronic periodontitis: A systematic review and meta-analysis

Zohaib Akram et al.

ARCHIVES OF ORAL BIOLOGY (2017)

Article Medicine, General & Internal

Increased cancer risk in patients with periodontitis

Omer Dizdar et al.

CURRENT MEDICAL RESEARCH AND OPINION (2017)

Review Peripheral Vascular Disease

Atherosclerosis, Periodontal Disease, and Treatment with Resolvins

James A. Hamilton et al.

CURRENT ATHEROSCLEROSIS REPORTS (2017)

Review Psychiatry

Depressed gut? The microbiota-diet-inflammation trialogue in depression

Margreet Koopman et al.

CURRENT OPINION IN PSYCHIATRY (2017)

Review Oncology

Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis

P. Maisonneuve et al.

ANNALS OF ONCOLOGY (2017)

Article Dentistry, Oral Surgery & Medicine

Human chemerin correlation in gingival crevicular fluid and tear fluid as markers of inflammation in chronic periodontitis and type-2 diabetes mellitus

Kaushik Patnaik et al.

JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY (2017)

Review Dentistry, Oral Surgery & Medicine

Parkinson's disease and periodontitis - the missing link? A review

Tejaswani Kaur et al.

GERODONTOLOGY (2016)

Article Pharmacology & Pharmacy

Therapeutic Targets for Management of Periodontitis and Diabetes

Corneliu Sima et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

Article Immunology

Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis

Chun-Teh Lee et al.

JOURNAL OF IMMUNOLOGY (2016)

Article Immunology

Role of bacteria in leukocyte adhesion deficiency-associated periodontitis

George Hajishengallis et al.

MICROBIAL PATHOGENESIS (2016)

Article Dentistry, Oral Surgery & Medicine

Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes

J. Valentine et al.

ORAL DISEASES (2016)

Article Oncology

Oral microbiome, periodontitis and risk of head and neck cancer

Leonardo Victor Galvao-Moreira et al.

ORAL ONCOLOGY (2016)

Review Dentistry, Oral Surgery & Medicine

Aging, inflammation, immunity and periodontal disease

Jeffrey L. Ebersole et al.

PERIODONTOLOGY 2000 (2016)

Review Gastroenterology & Hepatology

Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?

Ronaldo Lira-Junior et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Medicine, Research & Experimental

The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction

Bartlomiej Gorski et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2016)

Review Endocrinology & Metabolism

Osteoporosis and Periodontitis

Chin-Wei (Jeff) Wang et al.

CURRENT OSTEOPOROSIS REPORTS (2016)

Review Medicine, General & Internal

Epigenetics and Periodontitis: A Contemporary Review

Geetha Ari et al.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2016)

Article Dentistry, Oral Surgery & Medicine

Expression of periodontal inflammation into left ventricular hypertrophy in Type 2 diabetes mellitus: A cross-sectional study

Trupti Sarda et al.

CONTEMPORARY CLINICAL DENTISTRY (2016)

Review Dentistry, Oral Surgery & Medicine

Activation and resolution of periodontal inflammation and its systemic impact

Hatice Hasturk et al.

PERIODONTOLOGY 2000 (2015)

Article Immunology

The expression of gingival epithelial junctions in response to subgingival biofilms

Georgios N. Belibasakis et al.

VIRULENCE (2015)

Review Immunology

Periodontitis: from microbial immune subversion to systemic inflammation

George Hajishengallis

NATURE REVIEWS IMMUNOLOGY (2015)

Review Immunology

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

Melissa Noack et al.

AUTOIMMUNITY REVIEWS (2014)

Review Biochemistry & Molecular Biology

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

Mark D. Turner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Review Public, Environmental & Occupational Health

Mechanisms involved in the association between periodontitis and complications in pregnancy

MarcelaYang Hui Zi et al.

FRONTIERS IN PUBLIC HEALTH (2014)

Article Dentistry, Oral Surgery & Medicine

Gap-junction-mediated Communication in Human Periodontal Ligament Cells

R. Kato et al.

JOURNAL OF DENTAL RESEARCH (2013)

Review Dentistry, Oral Surgery & Medicine

Mobile Microbiome: Oral Bacteria in Extra-oral Infections and Inflammation

Y. W. Han et al.

JOURNAL OF DENTAL RESEARCH (2013)

Article Clinical Neurology

Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease

Pamela Sparks Stein et al.

ALZHEIMERS & DEMENTIA (2012)

Review Biotechnology & Applied Microbiology

Targeting IL-17and TH17 cells in chronic inflammation

Pierre Miossec et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Dentistry, Oral Surgery & Medicine

Genetic susceptibility to periodontitis

Marja L. Laine et al.

PERIODONTOLOGY 2000 (2012)

Article Medicine, General & Internal

Periodontal Disease in Children

Sahar Alrayyes et al.

DM DISEASE-A-MONTH (2011)

Article Dentistry, Oral Surgery & Medicine

Oxidative Stress, Systemic Inflammation, and Severe Periodontitis

F. D'Aiuto et al.

JOURNAL OF DENTAL RESEARCH (2010)

Review Dentistry, Oral Surgery & Medicine

The association between periodontal disease and cancer: A review of the literature

Sarah G. Fitzpatrick et al.

JOURNAL OF DENTISTRY (2010)

Article Dentistry, Oral Surgery & Medicine

The expressions of claudin-1 and E-cadherin in junctional epithelium

T. Fujita et al.

JOURNAL OF PERIODONTAL RESEARCH (2010)

Article Dentistry, Oral Surgery & Medicine

Rethinking Periodontal Inflammation

Steven Offenbacher et al.

JOURNAL OF PERIODONTOLOGY (2008)

Article Dentistry, Oral Surgery & Medicine

Cytokines That Promote Periodontal Tissue Destruction

Dana Graves

JOURNAL OF PERIODONTOLOGY (2008)

Review Infectious Diseases

Relationship between periodontal infections and systemic disease

G. J. Seymour et al.

CLINICAL MICROBIOLOGY AND INFECTION (2007)

Article Dentistry, Oral Surgery & Medicine

Systemic markers of inflammation in periodontitis

BG Loos

JOURNAL OF PERIODONTOLOGY (2005)

Article Dentistry, Oral Surgery & Medicine

Evidence of a substantial genetic basis for risk of adult periodontitis

BS Michalowicz et al.

JOURNAL OF PERIODONTOLOGY (2000)