Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.790321
Keywords
epigenetics; DNA methylation; Chinese herbal medicine; constitution theory; ethnopharmacology
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Funding
- National Natural Science Foundation of China [81803970, 81973714]
- Young Talent Promotion Project of China Association of Chinese Medicine [CACM-2019-QNRC2-A01]
- Young Scientists Development Program of Beijing University of Chinese Medicine
- Fundamental Research Funds for the Central Universities [2020-JYB-XJSJJ-003]
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DNA methylation plays a pleiotropic role in Chinese herbal medicine, influencing plant growth, bioactive compound biosynthesis, pharmaceutical mechanisms, and constitution theory validation, which contributes significantly to the development and research of Chinese herbal medicine.
Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance.
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