Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.762362
Keywords
nanomaterials; cationic polymer; autoimmune diseases; nanoparticles; cell-free DNA
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Funding
- National Key R&D Program of China [2019YFA0110500]
- International Science and Technology Cooperation Program of Guangdong Province [2019A050510028]
- Guangdong Pearl River Talents Program [2017GC010411]
- Ten and Five Project of the Third Affiliated Hospital of Sun Yat-sen University [SW201901]
- Distinguished young Scholar Candidates Program for The Third Affiliated Hospital of Sun Yat-sen University [A2675]
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This article reviews the potential and strategies of cationic nanomaterials in the treatment of autoimmune diseases, and discusses the challenges and possible solutions encountered during the development of cationic materials-based therapeutics for autoimmune diseases.
Cationic nanomaterials are defined as nanoscale structures smaller than 100 nm bearing positive charges. They have been investigated to apply to many aspects including clinical diagnosis, gene delivery, drug delivery, and tissue engineering for years. Recently, a novel concept has been made to use cationic nanomaterials as cell-free nucleic acid scavengers and inhibits the inflammatory responses in autoimmune diseases. Here, we highlighted different types of cationic materials which have the potential for autoimmune disease treatment and reviewed the strategy for autoimmune diseases therapy based on cationic nanoparticles. This review will also demonstrate the challenges and possible solutions that are encountered during the development of cationic materials-based therapeutics for autoimmune diseases.
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