Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.755871
Keywords
probiotic; chemotherapy; prebiotic; immunomodulant effects; symbiotic
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 151533/2018-0]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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The symbiotic product developed in this study shows significant improvement in symptoms of mucositis induced by 5-FU, including reducing weight loss and intestinal permeability, lowering inflammation score, and decreasing levels of pro-inflammatory cytokines.
Mucositis is an adverse effect of cancer chemotherapies using 5-Fluorouracil (5-FU). It is characterized by mucosal inflammation, pain, diarrhea, and weight loss. Some studies reported promising healing effects of probiotic strains, when associated with prebiotics, as adjuvant treatment of mucositis. We developed a lyophilized symbiotic product, containing skimmed milk, supplemented with whey protein isolate (WPI) and with fructooligosaccharides (FOS), and fermented by Lactobacillus casei BL23, Lactiplantibacillus plantarum B7, and Lacticaseibacillus rhamnosus B1. In a mice 5-FU mucositis model, this symbiotic lyophilized formulation was able to reduce weight loss and intestinal permeability. This last was determined in vivo by quantifying blood radioactivity after oral administration of 99mTc-DTPA. Finally, histological damages caused by 5-FU-induced mucositis were monitored. Consumption of the symbiotic formulation caused a reduced score of inflammation in the duodenum, ileum, and colon. In addition, it decreased levels of pro-inflammatory cytokines IL-1 beta, IL-6, IL-17, and TNF-alpha in the mice ileum. The symbiotic product developed in this work thus represents a promising adjuvant treatment of mucositis.
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