Pentagalloyl Glucose, a Major Compound in Mango Seed Kernel, Exhibits Distinct Gastroprotective Effects in Indomethacin-Induced Gastropathy in Rats via Modulating the NO/eNOS/iNOS Signaling Pathway

Article Environmental Sciences

Larvicidal Activity of Pentagalloyl Glucose and Mangiferin Isolated from the Waste of Mango Kernel Against Culex pipiens L.

Mahmoud Emam et al.

Summary: The study found that the waste of Mango seed kernels showed good larvicidal activity against Culex pipiens larvae, with the major compounds pentagalloyl glucose and mangiferin also exhibiting significant effects.

WASTE AND BIOMASS VALORIZATION (2022)

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Article Biochemistry & Molecular Biology

Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies

Mohamed Nabil et al.

Summary: The leaf extract of Albizia anthelmintica has significant antioxidant, anti-inflammatory, analgesic, and antipyretic properties. It showed gastroprotective effects in an indomethacin-induced ulcer model, preventing gastric lesions and maintaining gastric mucosa integrity through mechanisms involving anti-inflammatory and antioxidant activities, as well as regulation of iNOS levels. These findings suggest that Albizia anthelmintica could be a potential candidate for managing gastric ulcers with antioxidant properties.

ANTIOXIDANTS (2021)

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Article Pharmacology & Pharmacy

Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells

Jinzhi Tong et al.

Summary: The study demonstrated that PGG inhibits the JAK2/STAT3 cascade by activating Nrf2/HO-1 signaling, which in turn suppresses ROS generation and inflammatory cytokines induced by AGE. Moreover, the involvement of Nrf2 in blocking the JAK2/STAT3 cascade by PGG was confirmed using the Nrf2 transcriptional inhibitor ML385.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

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Article Plant Sciences

Gastroprotective activity of kaempferol glycosides from Malvaviscus arboreus Cav

Yrvinn Campos-Vidal et al.

Summary: The study found that the aqueous extract and its organic fraction from Malvaviscus arboreus contain glycosylated flavonoids which are responsible for its gastroprotective properties. These findings have the potential for future development of standardized treatments for therapeutic management of gastric ulcers.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells

Patricia Mendonca et al.

Summary: The study found that PGG has anti-cancer effects on TNF-alpha activated TNBC cell lines by reducing cell proliferation, inhibiting GRO-alpha release, and inducing apoptosis through increasing TNF and TNF family receptor expression.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection

Rui Hong Chen et al.

Summary: The study revealed that PGG may effectively combat COVID-19 by blocking the fusion of SARS-CoV-2 spike RBD to hACE2 receptors, showing potential antiviral properties and demonstrating high safety in animal experiments.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Systemic delivery of targeted nanotherapeutic reverses angiotensin II-induced abdominal aortic aneurysms in mice

Xiaoying Wang et al.

Summary: AAA disease is a serious condition with no effective pharmacotherapies currently available. Through the conjugation of nanoparticles with elastin antibodies, targeted delivery of drugs to the aneurysm site was achieved, improving the mechanical properties of the aorta at the AAA site and potentially serving as an effective treatment option for early to middle stage AAA.

SCIENTIFIC REPORTS (2021)

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Article Physiology

Interplay of Biochemical, Genetic, and Immunohistochemical Factors in the Etio-Pathogenesis of Gastric Ulcer in Rats: A Comparative Study of the Effect of Pomegranate Loaded Nanoparticles Versus Pomegranate Peel Extract

Nessren M. Abd El-Rady et al.

Summary: Both pomegranate loaded nanoparticles (PLN) and pomegranate peel extract (PPE) effectively alleviated indomethacin (IND)-induced gastric ulceration by increasing total antioxidant capacity, prostaglandin E-2, nitric oxide, endothelial nitric oxide synthase mRNA, and protein expression. However, the healing effect of PLN was significantly greater than that of PPE.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Medicine, Research & Experimental

Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-KB signaling pathway in rats

Mona F. Mahmoud et al.

Summary: This study investigated the gastroprotective potential of wax apple leaf extract on indomethacin-induced gastric ulcer in rats and explored the underlying mechanisms. The results showed that the leaf extract exhibited significant gastroprotective effects, potentially attributed to its cytoprotective, antioxidant, anti-inflammatory, and antiapoptotic activities, with a possible involvement of EP3 and EP4 receptors.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Geriatrics & Gerontology

Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans

Xiaoying Zhang et al.

Summary: The study demonstrated that PGG has significant immunomodulatory effects, inhibiting the secretion of inflammatory factors and enhancing immunomodulation in C. elegans through multiple signaling pathways. The findings suggest the potential of PGG to be developed into novel immunomodulatory nutraceuticals.

EXPERIMENTAL GERONTOLOGY (2021)

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Article Medicine, Research & Experimental

Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling

Maha A. E. Ahmed et al.

Summary: Chlorogenic acid (CGA) showed a dose-dependent gastroprotective effect by reversing IND-induced accumulation of autophagic vacuoles and down-regulation of related markers, while also restoring normal autolysosomal function and impairing IND-induced apoptosis through modulation of apoptotic proteins. The mechanism involves a crosstalk mediated by Akt/mTOR pathway reactivation and alleviation of IND-induced lysosomal dysfunction.

LIFE SCIENCES (2021)

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Review Chemistry, Medicinal