4.7 Article

β2-and β3-Adrenergic Receptors Contribute to Cancer-Evoked Pain in a Mouse Model of Osteosarcoma via Modulation of Neural Macrophages

Journal

FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.697912

Keywords

beta-adrenergic receptors; cancer pain; osteosarcoma; neuroinflammation; macrophages

Funding

  1. AIRC [24503]

Ask authors/readers for more resources

The study found that beta-ARs play a role in cancer pain, with antagonists for beta 2-and beta 3-ARs slowing down mechanical allodynia and the development of macrophages, while also reducing the accumulation of oxidative stress byproducts.
The mechanisms involved in the development and maintenance of cancer pain remain largely unidentified. Recently, it has been reported that beta-adrenergic receptors (beta-ARs), mainly beta 2-and beta 3-ARs, contribute to tumor proliferation and progression and may favor cancer-associated pain and neuroinflammation. However, the mechanism underlying beta-ARs in cancer pain is still unknown. Here, we investigated the role of beta 1-, beta 2-and beta 3-ARs in a mouse model of cancer pain generated by the para-tibial injection of K7M2 osteosarcoma cells. Results showed a rapid tumor growth in the soft tissue associated with the development of mechanical allodynia in the hind paw ipsilateral to the injected site. In addition to reduce tumor growth, both propranolol and SR59230A, beta 1-/beta 2-and beta 3-AR antagonists, respectively, attenuated mechanical allodynia, the number of macrophages and an oxidative stress by-product accumulated in the ipsilateral tibial nerve. The selective beta 1-AR antagonist atenolol was able to slightly reduce the tumor growth but showed no effect in reducing the development of mechanical allodynia. Results suggest that the development of the mechanical allodynia in K7M2 osteosarcoma-bearing mice is mediated by oxidative stress associated with the recruitment of neural macrophages, and that antagonism of beta 2-and beta 3-ARs contribute not solely to the reduction of tumor growth, but also in cancer pain. Thus, the targeting of the beta 2-and beta 3-ARs signaling may be a promising therapeutic strategy against both tumor progression and the development of cancer-evoke pain in osteosarcoma.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available