Journal
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
Volume 33, Issue 1, Pages 5-11Publisher
SPRINGER
DOI: 10.1007/s10554-016-0968-z
Keywords
Optical coherence tomography; Attenuation; Lipid core plaque
Funding
- Netherlands Heart Foundation [2010B064]
- Heart Research UK [RG2608/12/14]
- National Institute for Health Research Bristol Cardiovascular Biomedical Research Unit
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Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r(2) > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.
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