Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.705023
Keywords
neuropathic pain; analgesic effect; Kampo formula; Kampo medicine; Yokukansan
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Kampo medicine, a traditional medicine practiced in Japan, uses formulae composed of multiple crude drugs to treat various conditions. These formulae are often used in place of or in combination with Western medicines, with Yokukansan (YKS) emerging as a popular choice for pain treatment. The holistic healing properties of Kampo formulae are attributed to their combination of natural ingredients with pharmacological effects.
Kampo medicine has been practiced as traditional medicine (TM) in Japan. Kampo medicine uses Kampo formulae that are composed of multiple crude drugs to make Kampo formulae. In Japan, Kampo formulae are commonly used instead of or combined with Western medicines. If drug therapy that follows the guidelines for neuropathic pain does not work or cannot be taken due to side effects, various Kampo formulae are considered as the next line of treatment. Since Kampo formulae are composed of two or more kinds of natural crude drugs, and their extracts contain many ingredients with pharmacological effects, one Kampo formula usually has multiple effects. Therefore, when selecting a formula, we consider symptoms other than pain. This review outlines the Kampo formulae that are frequently used for pain treatment and their crude drugs and the basic usage of each component. In recent years, Yokukansan (YKS) has become one of the most used Kampo formulae for pain treatment with an increasing body of baseline research available. We outline the known and possible mechanisms by which YKS exerts its pharmacologic benefits as an example of Kampo formulae's potency and holistic healing properties.
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