Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.799397
Keywords
brain organoid; neural toxicity; brain organoid transplantation; vascularization; assembloid
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Funding
- National Key Research and Development Program of China [2021YFA1101803, 2019YFA0802703]
- National Natural Science Foundation of China [81922022, 91849117]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16010306]
- Jiangsu Province Innovative and Entrepreneurial Team
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This study reviews the recent advances in brain organoid techniques and their application in assessing neural toxicants. Brain organoids with self-assembled 3D structures provide opportunities for testing and predicting human neurotoxicity.
The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases. Animal models may not fully recapitulate the human brain for testing neural toxicity. Brain organoids with self-assembled three-dimensional (3D) structures provide opportunities to generate relevant tests or predictions of human neurotoxicity. In this study, we reviewed recent advances in brain organoid techniques and their application in assessing neural toxicants. We hope this review provides new insights for further progress in brain organoid application in the screening studies of neural toxicants.
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