Journal
FEBS OPEN BIO
Volume 12, Issue 1, Pages 146-153Publisher
WILEY
DOI: 10.1002/2211-5463.13314
Keywords
autophagy; breast cancer; ferroptosis; H19; metformin
Categories
Funding
- Zhejiang Provincial Natural Science Foundation of China [LY20H160026]
- Zhejiang Provincial Department of Education Scientific Research Project [Y200805402]
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Research has shown that metformin and long non-coding RNA H19 can impact the treatment outcomes of breast cancer by regulating autophagy and ferroptosis.
Autophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation of their intrinsic molecular relationships is important for cancer prevention and treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible for this is not fully understood. Here, we demonstrate that metformin and lncRNA-H19 can regulate both autophagy and ferroptosis. Autophagy inducers and H19 can reverse the production of lipid reactive oxygen species and the inhibition of autophagy induced by metformin. The present study suggests that metformin may induce ferroptosis by inhibiting autophagy via H19, and this discovery may facilitate the development of novel therapies for the treatment of breast cancer.
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