Journal
CURRENT CARDIOLOGY REPORTS
Volume 23, Issue 11, Pages -Publisher
SPRINGER
DOI: 10.1007/s11886-021-01596-y
Keywords
Physical activity; Cardiorespiratory fitness; Cardiovascular disease; Risk prediction; Prevention
Categories
Funding
- Texas Health Resources Clinical Scholarship
- Gilead Sciences Research Scholar Program
- National Institute on Aging GEMSSTAR Grant [1R03AG067960-01]
- National Institutes of Health [2T32HL125247-06]
- Applied Therapeutics
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Physical activity and cardiorespiratory fitness are independently associated with cardiovascular disease morbidity and mortality, and improving cardiorespiratory fitness can reduce cardiovascular disease risk. Incorporating information on physical activity and cardiorespiratory fitness into cardiovascular disease risk assessment models significantly improves risk prediction.
Purpose of Review Current risk prediction tools do not include physical activity (PA) or cardiorespiratory fitness (CRF), despite their robust association with adverse cardiovascular disease (CVD) events and their potential as targets for preventive interventions. Recent Findings PA and CRF are each associated with cardiovascular (CV) morbidity and mortality, independent of traditional risk factors. Improvement in CRF is associated with reduced risk of atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF). Risk prediction tools have been developed for ASCVD, and more recently for HF, to refine CVD risk assessment and inform CVD prevention strategies. Attempts have been made to incorporate PA and CRF into available CVD risk prediction models. Inclusion of PA and CRF into established CVD risk assessment models improves CVD risk prediction incremental to established CVD risk prediction tools, suggesting PA and CRF are markers of CVD risk and targets for CVD prevention.
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