Journal
CANCER IMMUNOLOGY RESEARCH
Volume 10, Issue 2, Pages 228-244Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2326-6066.CIR-20-1023
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Funding
- National Science Centre [2015/19/B/NZ6/02862, 2019/33/B/NZ6/02503]
- European Research Council [805038/STIMUNO/ERC-2018-STG]
- iONKO from the Polish Ministry of Education and Science [013/RID/2018/19]
- Polish Ministry of Education and Science [419273/PnH/2018]
- Polish National Science Centre [2019/35/O/ST6/02484, 2020/37/B/NZ2/03757]
- Foundation for Polish Science - European Union under the European Regional Development Fund
- Polpharma Scientific Foundation
- IDUB against COVID-19 project - Warsaw University of Technology under the program Excellence Initiative: Research University (IDUB)
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Oxidative stress is a characteristic feature of cancer, and increased hydrogen peroxide concentrations affect immune cell functions. NK cells are more susceptible to hydrogen peroxide and lack peroxiredoxin-1.
Oxidative stress, caused by the imbalance between reactive species generation and the dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer. Here, we quantified hydrogen peroxide in the tumor microenvironment (TME) and demonstrated that hydrogen peroxide concentrations are elevated in tumor interstitial fluid isolated from murine breast cancers in vivo, when compared with blood or normal subcutaneous fluid. Therefore, we investigated the effects of increased hydrogen peroxide concentration on immune cell functions. NK cells were more susceptible to hydrogen peroxide than T cells or B cells, and by comparing T, B, and NK cells' sensitivities to redox stress and their antioxidant capacities, we identified peroxiredoxin-1 (PRDX1) as a lacking element of NK cells' antioxidative defense. We observed that
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