4.7 Article

Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

Related references

Note: Only part of the references are listed.
Article Psychiatry

A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis

Boris Chaumette et al.

Summary: Schizophrenia is a mental illness characterized by positive symptoms, negative symptoms, and cognitive impairments. This study found an association between genetic variations in genes coding for glutamatergic receptors and cognitive impairment in schizophrenia, suggesting potential drug targets.

SCHIZOPHRENIA RESEARCH (2022)

Article Biochemistry & Molecular Biology

A polygenic resilience score moderates the genetic risk for schizophrenia

Jonathan L. Hess et al.

Summary: This study proposed a theoretical framework based on genetic variations that promote resilience to highly heritable polygenic disorders, such as schizophrenia. By establishing a procedure to identify unaffected individuals with relatively high polygenic risk for the disease and generating the first known polygenic resilience score, this work laid a foundation for finding resilience variants for any complex, heritable disorder.

MOLECULAR PSYCHIATRY (2021)

Article Genetics & Heredity

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction

Perline A. Demange et al.

Summary: Genomic structural equation modeling was used to estimate the genetic component of educational attainment independent of cognitive ability, finding that 57% of genetic variation in educational attainment is attributed to noncognitive skills. The study identified significant loci and a polygenic architecture contributing to educational attainment, with noncognitive genetics showing associations with personality traits, behavior, and psychiatric disorders. Noncognitive and cognitive-performance genetics were found to be similarly associated with socioeconomic success and longevity.

NATURE GENETICS (2021)

Article Psychiatry

The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

Alexander L. Richards et al.

SCHIZOPHRENIA BULLETIN (2020)

Article Biochemistry & Molecular Biology

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

Olav B. Smelan et al.

MOLECULAR PSYCHIATRY (2020)

Article Genetics & Heredity

A principal component approach to improve association testing with polygenic risk scores

Brandon J. Coombes et al.

GENETIC EPIDEMIOLOGY (2020)

Article Genetics & Heredity

Genome-wide association study identifies 30 loci associated with bipolar disorder

Eli A. Stahl et al.

NATURE GENETICS (2019)

Article Biology

PRSice-2: Polygenic Risk Score software for biobank-scale data

Shing Wan Choi et al.

GIGASCIENCE (2019)

Article Behavioral Sciences

Polygenic risk for schizophrenia and neurocognitive performance in patients with schizophrenia

S. -H. Wang et al.

GENES BRAIN AND BEHAVIOR (2018)

Review Neurosciences

Neuropsychology of subjects with ultra-high risk (UHR) of psychosis: A critical analysis of the literature

C. Mam-lam-Fook et al.

ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE (2017)

Article Genetics & Heredity

Who's Who? Detecting and Resolving Sample Anomalies in Human DNA Sequencing Studies with Peddy

Brent S. Pedersen et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Genetics & Heredity

An atlas of genetic correlations across human diseases and traits

Brendan Bulik-Sullivan et al.

NATURE GENETICS (2015)

Article Neurosciences

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power et al.

NATURE NEUROSCIENCE (2015)

Article Neurosciences

Assessment of mental states at risk of psychotic transition: Validation of the French version of the CAARMS

M. -O. Krebs et al.

ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE (2014)

Article Multidisciplinary Sciences

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke et al.

NATURE (2014)

Review Psychiatry

The Psychosis High-Risk State A Comprehensive State-of-the-Art Review

Paolo Fusar-Poli et al.

JAMA PSYCHIATRY (2013)

Article Psychiatry

Substantial genetic overlap between neurocognition and schizophrenia - Genetic modeling in twin samples

Timothea Toulopoulou et al.

ARCHIVES OF GENERAL PSYCHIATRY (2007)

Article Psychology, Clinical

Trail Making Test A and B: Normative data stratified by age and education

TN Tombaugh

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2004)