Journal
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
Volume 104, Issue 1, Pages 141-148Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02772248.2021.1996577
Keywords
Escin; acute toxicity; repeated dose toxicity; Aesculus hippocastanum Aesculus indica; triterpene saponins
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In animal studies using escin, it was found that high doses could be toxic, but no signs of toxicity were observed at lower doses, making it safe for use.
Escin has effects on inflammation and is useful for the treatment of varicose veins and cancer. Scientific reports on the toxicity profile of escin are not available. Oral acute toxicity in rats was studied. At 2000 mg/kg, escin was lethal to all animals while at 300 mg/kg no signs of toxicity, changes in body weight, food and water consumption were observed within 14 days. A 28-days oral toxicity study was performed at daily doses of 5, 10, and 20 mg/kg of escin. Bodyweight, food, and water intake were not altered. There were neither significant changes in biochemical and hematological parameters nor any histopathological changes in organs after treatment with escin for 28 days. Escin was found to be safe at all selected dose levels in a repeated dose toxicity study.
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