Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 220, Issue -, Pages 122-128Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2016.06.030
Keywords
Coronary disease; Risk factors; Cerebrovascular disorders; Epidemiology
Categories
Funding
- National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service [U01 NS041588]
- National Heart, Lung, and Blood Institute [R01 HL080477, K24 HL111154]
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Background: Many adults without cerebrovascular disease report a history of stroke symptoms, which is associated-with higher risk for stroke. Because stroke and coronary heart disease (CHD) share many risk factors, we examined the association between a history of stroke symptoms and incident CHD. Methods: We analyzed data from 8999 black and 12,499 white REasons for Geographic And Racial Differences in Stroke (REGARDS) study participants without a prior myocardial infarction, stroke or transitory ischemic attack enrolled in 2003-2007 (total participants = 21,498, all = 45 years of age). A history of stroke symptoms (i.e., unilateral weakness, unilateral numbness, full-field vision loss, half-field vision loss, understanding problems and communication problems) was assessed at baseline using the Questionnaire for Verifying Stroke-Free Status. Participants were followed for incident CHD and CHD death through December 2011. Results: Overall, 3432 (16.0%) participants reported a history of stroke symptoms (1771 [19.7%] blacks and 1661 [13.3%] whites). There were 701 incident CHD events including 209 CHD deaths over a median follow-up of 5.8 years. After adjustment for CHD risk factors, hazard ratios (95% confidence interval [95% CI]) for incident CHD associated with reporting any versus no stroke symptoms were 1.26 (1.04-1.51) in the overall population, 1.28 (0.99-1.65) among blacks and 1.23 (0.94-1.61) among whites. Multivariable-adjusted hazard ratios (95% CI) for CHD death associated with any versus no stroke symptoms were 1.50 (1.10-2.06) overall, 1.58 (1.07-2.32) among blacks and 1.41 (0.82-2.43) among whites. Conclusion: A history of stroke symptoms is associated with a higher incidence of CHD among black and white adults. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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