Journal
STEM CELLS INTERNATIONAL
Volume 2022, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2022/7153584
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [81871752]
- Natural Science Foundation of Hubei Province [2020CFB551]
- Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund [cxpy2019074]
- Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University [ZNJC202014]
Ask authors/readers for more resources
Critical bone defects and delayed union and nonunion remain challenges worldwide. Bone tissue engineering, utilizing mesenchymal stem cells (MSCs), aims to achieve satisfactory bone reconstruction. Immune responses, including innate and adaptive reactions, play important roles in bone regeneration. MSCs and immune cells regulate each other, and various immune cells and cytokines can modulate the migration, proliferation, and osteogenic differentiation of MSCs. Understanding the principles of bone immunology is crucial for the practical application of bone tissue engineering.
Critical bone defects and related delayed union and nonunion are still worldwide problems to be solved. Bone tissue engineering is mainly aimed at achieving satisfactory bone reconstruction. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells that can differentiate into bone cells and can be used as one of the key pillars of bone tissue engineering. In recent decades, immune responses play an important role in bone regeneration. Innate immune responses provide a suitable inflammatory microenvironment for bone regeneration and initiate bone regeneration in the early stage of fracture repair. Adaptive immune responses maintain bone regeneration and bone remodeling. MSCs and immune cells regulate each other. All kinds of immune cells and secreted cytokines can regulate the migration, proliferation, and osteogenic differentiation of MSCs, which have a strong immunomodulatory ability to these immune cells. This review mainly introduces the interaction between MSCs and immune cells on bone regeneration and its potential mechanism, and discusses the practical application in bone tissue engineering by modulating this kind of cell-to-cell crosstalk. Thus, an in-depth understanding of these principles of bone immunology can provide a new way for bone tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available