4.6 Article

Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

Journal

MICROMACHINES
Volume 13, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/mi13020200

Keywords

microfluidic technology; drug development; drug carrier; micro; nanoparticles; drug toxicity screening; organs-on-chips

Funding

  1. Shandong Provincial Key RD Project [2021CXGC010515]
  2. Double Hundred Plan of Shandong Province [WST2017001]
  3. International S&T Cooperation Program of Shandong Academy of Sciences [2019GHPY06]

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This article introduces the applications of microfluidic technology in drug development, focusing on the recent developments and trends in microfluidic fabrication of drug carriers and microfluidic chips for drug toxicity screening. The challenges and future directions of microfluidic applications in drug development are also discussed.
Microfluidic technology has been highly useful in nanovolume sample preparation, separation, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

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