New Era of Electroceuticals: Clinically Driven Smart Implantable Electronic Devices Moving towards Precision Therapy

Article Polymer Science

Enhanced electrochemical performance of neural electrodes based on PEDOT:PSS hydrogel

Qi Zeng et al.

Summary: The conductive polymer hydrogel (CPH) made from PEDOT:PSS successfully modified on platinum (Pt) substrate exhibited excellent performance, providing great potential for applications in neural implants and other flexible electronics.

JOURNAL OF APPLIED POLYMER SCIENCE (2022)

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Article Engineering, Electrical & Electronic

Implantable Radio Frequency Powered Gastric Electrical Stimulator

Souvik Dubey et al.

Summary: This study introduces a new battery-less gastric stimulator powered by wireless radio-frequency, which delivers controlled electrical pulses to stomach tissues to restore normal motility and contraction.

IEEE JOURNAL OF ELECTROMAGNETICS RF AND MICROWAVES IN MEDICINE AND BIOLOGY (2022)

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Article Clinical Neurology

Optimizing Dosing of Vagus Nerve Stimulation for Stroke Recovery

David T. Pruitt et al.

Summary: The study found that moderate-intensity VNS paired with rehabilitation training maximizes recovery of motor function in models of ischemic stroke. VNS at 0.8 mA was beneficial for functional recovery, while VNS at 0.4 mA and 1.6 mA were not sufficient to improve recovery compared to equivalent rehabilitation without VNS.

TRANSLATIONAL STROKE RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Self-powered cardiovascular electronic devices and systems

Qiang Zheng et al.

Summary: This article discusses the use of self-powered technology to harvest energy from the body and its ambient environment to power cardiovascular electronic devices, in order to extend battery life and enhance device functionality. It also introduces the main goals of current self-powered electronic devices applied in the cardiovascular field.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Biophysics

A comprehensive review of powering methods used in state-of-the-art miniaturized implantable electronic devices

H. Dinis et al.

Summary: Microfabrication techniques, sensor and actuator miniaturization, optimization of microelectronic circuits, and wireless communication capabilities have enabled the development of implants for previously impossible applications. However, the scaling down of implants raises challenges in powering them, leading to emerging energy sources that do not rely on batteries. This paper reviews recent implantable bioelectronic devices that employ alternative powering methods and discusses their suitability for future devices.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Biology

Flexible and stretchable polymer optical fibers for chronic brain and vagus nerve optogenetic stimulations in free-behaving animals

Yi Cao et al.

Summary: This study developed flexible and stretchable polymer optical fibers (POFs) for in vivo optogenetic applications, which showed significantly improved characteristics compared to traditional silica optical fibers. The POFs were successfully implanted into the primary motor cortex and used for vagus nerve optogenetic stimulation (VNOS), demonstrating the feasibility and advantages of chronic optogenetic modulations in both central and peripheral nervous systems. This approach provides new insights for the development of novel therapeutic strategies for neuropsychiatric disorders.

BMC BIOLOGY (2021)

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Article Engineering, Biomedical

An Efficient Noninvasive Neuromodulation Modality for Overactive Bladder Using Time Interfering Current Method

Jiho Lee et al.

Summary: The new tibial nerve stimulation (TNS) modality using interferential currents, known as ICT, has shown high penetration efficiency and physiological effectiveness. Simulation and in vivo experiments confirmed that ICT generates a stronger field near the nerve compared to conventional TENS. The results suggest that ICT-TNS is more efficient and effective in treating conditions like OAB compared to TENS-TNS.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2021)

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Article Engineering, Electrical & Electronic

Modelling and analysis of a modified preamplifier for seizure detection

Swagata Devi et al.

Summary: This paper presents a modified recycling folded cascode amplifier intended for use in an epileptic neurostimulator circuit. The design employs an adaptive biasing technique and operates in weak inversion region for ultra-low power consumption.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2021)

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Article Engineering, Electrical & Electronic

An Optically Addressed Nanowire-Based Retinal Prosthesis With Wireless Stimulation Waveform Control and Charge Telemetering

Abraham Akinin et al.

Summary: This article introduces an inductively powered wireless SoC for an electrically controlled, optically addressed retinal prosthetic system, achieving reduced thermal dissipation near sensitive retinal tissue and charge-balanced stimulation control.

IEEE JOURNAL OF SOLID-STATE CIRCUITS (2021)

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Article Engineering, Electrical & Electronic

Transcutaneous Energy Transfer System for Cardiac-Assist Devices by Use of Inhomogeneous Biocompatible Core Material

Hossein Fazeli Khalili et al.

Summary: A novel magnetic liquid silicone rubber composite core design for wireless power transfer (WPT) in medical applications is presented and successfully integrated with ventricular-assist devices (VADs). By optimizing the design, the WPT efficiency is significantly increased and the temperature rise is reduced, making the power transfer more stable.

IEEE TRANSACTIONS ON MAGNETICS (2021)

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Article Chemistry, Physical

Self-powered cardiac pacemaker by piezoelectric polymer nanogenerator implant

Sara Azimi et al.

Summary: The study demonstrates a battery-free heart pacemaker powered by a polymer-based piezoelectric nanogenerator (PNG) that generates electricity from cardiac motions of the left ventricle, providing power to patients successfully. By optimizing the composite nanofiber design, the power output is maximized for effective energy harvesting.

NANO ENERGY (2021)

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Review Engineering, Electrical & Electronic

Stretchable transistors and functional circuits for human-integrated electronics

Yahao Dai et al.

Summary: The article reviews the development of stretchable transistors and functional circuits, examining progress in terms of materials and device engineering. The authors discuss the three established approaches for creating stretchable transistors and explore the current capabilities of stretchable transistors and circuits in human-integrated electronics, as well as the challenges involved in delivering advanced applications.

NATURE ELECTRONICS (2021)

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Article Engineering, Biomedical

In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator

Parinaz Abiri et al.

Summary: Researchers developed a wireless power transfer system for cardiac pacing to reduce complications associated with traditional pacemaker leads. The device safety was validated through computational modeling, and a pacemaker meeting the constraints of the anterior cardiac vein was fabricated. Experimental results demonstrated successful intravascular cardiac pacing with the wireless system.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

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Review Neurosciences

Brain-Machine Interfaces to Assist the Blind

Maurice Ptito et al.

Summary: The loss of vision is a significant challenge for individuals, leading to research on sensory substitution and cross-modal plasticity in recent decades. Both concepts require training, as efforts continue to develop modern technologies to assist blind individuals. Brain imaging has provided insight into the neural processes involved in sensory substitution, highlighting the importance of rewiring the brain for alternative sensory input.

FRONTIERS IN HUMAN NEUROSCIENCE (2021)

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Article Cardiac & Cardiovascular Systems

Percutaneous management of superior vena cava syndrome in patients with cardiovascular implantable electronic devices

James Gabriels et al.

Summary: In this study, we found that combining transvenous lead extraction (TLE) with percutaneous treatment for symptomatic SVC syndrome is a safe and effective strategy. Over a 14-year period, 16 out of more than 1600 TLEs were performed for symptomatic SVC syndrome, with a high success rate in symptom relief during a median follow-up of 5.5 years.

HEART RHYTHM (2021)

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Article Medicine, General & Internal

Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception

David K. Turok et al.

Summary: In the United States, more women choose levonorgestrel IUDs over copper IUDs for long-term contraception. This study found that the levonorgestrel IUD is noninferior to the copper IUD for emergency contraception. Adverse events were similar between the two groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Chemistry, Physical

Wireless electrical stimulation of the vagus nerves by ultrasound-responsive programmable hydrogel nanogenerators for anti-inflammatory therapy in sepsis

Ping Chen et al.

Summary: This study presents a wireless-powered battery-free vagus nerves stimulator based on implantable high-performance hydrogel nanogenerators, showing promising application in anti-inflammatory therapy for sepsis. Development of programmable, battery-free neurostimulators for wireless electrical stimulation of nerve systems is an emerging research field.

NANO ENERGY (2021)

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Article Chemistry, Physical

Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation

Yuanzheng Zhang et al.

Summary: A self-powered VNS device was designed to stimulate the vagus nerve by harvesting biomechanical energy from carotid artery pulsation using a piezoelectric nanogenerator. The flexible PENGs, prepared through electrospinning and layer-by-layer assembly, showed outstanding output performance due to their multi-unit structure and improved stress distribution. This novel concept not only broadens the application scope of flexible PENG for energy harvesting but also demonstrates the potential for a self-powered vagal neuromodulation system.

NANO ENERGY (2021)

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Article Ophthalmology

A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: Interim Clinical Trial Results

Matthew A. Petoe et al.

Summary: The study investigated the safety and efficacy of a second-generation suprachoroidal retinal prosthesis in four subjects with advanced retinitis pigmentosa. The results showed significant improvements in functional vision and quality of life for the subjects after device activation, indicating the potential clinical usefulness of this prosthesis.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Dense Packed Drivable Optrode Array for Precise Optical Stimulation and Neural Recording in Multiple-Brain Regions

Longchun Wang et al.

Summary: The research introduces a new three-dimensional high-density drivable optrode array for multiple-brain recording and precise optical stimulation. With optimized recording performance of microelectrodes and precise implantation depth control, long-term tracking of neural activities has been achieved through this innovative technology.

ACS SENSORS (2021)

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Article Engineering, Biomedical

Toward living neuroprosthetics: developing a biological brain pacemaker as a living neuromodulatory implant for improving parkinsonian symptoms

Jordan Prox et al.

Summary: This study focuses on developing a biological brain pacemaker for treating Parkinson's disease through engineering strategies to create a multicellular biological circuit with cellular specificity. The results demonstrate the feasibility of fabricating a 3D multicellular circuit device in an implantable form, laying the foundation for designing a high-frequency pacing system for therapeutic neurostimulation. Autologous living neural implants may be the future solution to the limitations of electronic implants, providing lifelong robustness for patients with Parkinson's disease.

JOURNAL OF NEURAL ENGINEERING (2021)

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Article Neurosciences

Minimizing Iridium Oxide Electrodes for High Visual Acuity Subretinal Stimulation

Samir Damle et al.

eNeuro (2021)

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Review Materials Science, Multidisciplinary

Wearable, Implantable, and Interventional Medical Devices Based on Smart Electronic Skins

Lili Wang et al.

Summary: Recent advances in soft, flexible, and stretchable sensors have provided an opportunity to design various types of wearable flexible medical devices. The integration of biofunctionability with electronic skin has improved the biocompatibility, sensing capabilities, and mechanical flexibility of medical devices. These devices can detect a variety of physiological information simultaneously, opening up new possibilities for medical applications.

ADVANCED MATERIALS TECHNOLOGIES (2021)

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Article Energy & Fuels

Inductive Power Transfer Link at 13.56 MHz for Leadless Cardiac Pacemakers

Krithikaa Mohanarangam et al.

Summary: Inductive power transfer is a viable solution for long-term powering of cardiac pacemakers, with a 3-coil design at 13.56 MHz proving efficient for modern leadless cardiac pacemakers. The design successfully avoids exceeding SAR limits and ensures uninterrupted power supply while maintaining reliable performance in various alignment scenarios. Simulations and experiments demonstrate the system's ability to deliver power within safe levels, with transmission coefficients and power delivery efficiency meeting desired standards.

ENERGIES (2021)

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Article Psychiatry

Acute effect of vagus nerve stimulation (VNS) on brain function

Erhan Kavakbasi et al.

Summary: The study utilized MEG recording to assess the effects of VNS treatment for depression, demonstrating changes in alpha amplitude. Further research may help elucidate the mechanism of action of VNS in treating depression.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Article Multidisciplinary Sciences

Self-rechargeable cardiac pacemaker system with triboelectric nanogenerators

Hanjun Ryu et al.

Summary: Self-powered implantable devices have the potential to extend device operation time, but current energy harvesters are insufficient and inconvenient. The authors report on a commercial coin battery-sized high-performance inertia-driven triboelectric nanogenerator based on body motion and gravity, which can be used to charge a lithium-ion battery and integrated into a cardiac pacemaker.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Physical

Biocompatible, High-Performance, Wet-Adhesive, Stretchable All-Hydrogel Supercapacitor Implant Based on PANI@rGO/Mxenes Electrode and Hydrogel Electrolyte

Yang Liu et al.

Summary: An all-hydrogel micro-supercapacitor with lightweight, thin, stretchable and wet-adhesive properties, high areal capacitance, and energy density has been developed for functional bioelectronic implants. The micro-supercapacitor shows promising in vitro and in vivo biocompatibility when evaluated with cardiomyocytes and mice models. This research provides a new direction for future bio-integration of electronic systems.

ADVANCED ENERGY MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Wireless Addressable Cortical Microstimulators Powered by Near-Infrared Harvesting

Ah-Hyoung Lee et al.

Summary: This study demonstrates the concept of a distributed, untethered, and addressable microstimulator called "optical neurograin (ONG)", which can trigger stimulation events through remote command. Each ONG has a unique device address and can deliver current stimuli to the target cortex, enabling a stimulator network of up to 128 nodes.

ACS SENSORS (2021)

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Article Computer Science, Information Systems

Acoustic Power Transfer Using Self-Focused Transducers for Miniaturized Implantable Neurostimulators

Kyungmin Kim et al.

Summary: An innovative neurostimulator utilizing acoustic power transfer was proposed in this study. The device, which was small enough to be implanted with a small incision, consisted of a self-focused 3.6 MHz acoustic transducer and a receiver circuit. The optimized pair of transducers with a receiver circuit successfully transmitted stimulation pulses, demonstrating the feasibility of stimulation through an in vivo experiment.

IEEE ACCESS (2021)

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Review Pharmacology & Pharmacy

3D printing technology as innovative solutions for biomedical applications

Zaisam Al-Dulimi et al.

Summary: Recent developments in 3D printing technology have led to various applications in the medical field, such as drug delivery systems, tissue engineering, and prosthetics. While these applications have great benefits, there are also limitations and challenges that need to be addressed.

DRUG DISCOVERY TODAY (2021)

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Article Energy & Fuels

Design and Implementation of a Wireless Charging-Based Cardiac Monitoring System Focused on Temperature Reduction and Robust Power Transfer Efficiency

Dongwook Kim et al.

ENERGIES (2020)

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Article Energy & Fuels

A Wireless Power Transfer Based Implantable ECG Monitoring Device

Junho Kim et al.

ENERGIES (2020)

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Article Multidisciplinary Sciences

Analyzing the advantages of subcutaneous over transcutaneous electrical stimulation for activating brainwaves

Wonok Kang et al.

SCIENTIFIC REPORTS (2020)

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Review Neurosciences

Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice

Jonathan Y. Y. Yap et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Engineering, Biomedical

A 340 nW/Channel 110 dB PSRR Neural Recording Analog Front-End Using Replica-Biasing LNA, Level-Shifter Assisted PGA, and Averaged LFP Servo Loop in 65 nm CMOS

Liangjian Lyu et al.

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (2020)

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Article Chemistry, Analytical

A Scalable and Low Stress Post-CMOS Processing Technique for Implantable Microsensors

Ah-Hyoung Lee et al.

MICROMACHINES (2020)

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Article Chemistry, Physical

Nanocomposite engineered carbon fabric-mat as a passive metamaterial for stealth application

RaviPrakash Magisetty et al.

JOURNAL OF ALLOYS AND COMPOUNDS (2020)

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Article Clinical Neurology

Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Stroke: One-Year Follow-up

Jesse Dawson et al.

NEUROREHABILITATION AND NEURAL REPAIR (2020)

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Review Cardiac & Cardiovascular Systems

Electromagnetic interference in cardiac electronic implants caused by novel electrical appliances emitting electromagnetic fields in the intermediate frequency range: a systematic review

Sarah Driessen et al.

EUROPACE (2019)

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Article Materials Science, Multidisciplinary

Terpolymer (ABS) cermet (Ni-NiFe2O4) hybrid nanocomposite engineered 3D-carbon fabric mat as a X-band electromagnetic interference shielding material

RaviPrakash Magisetty et al.

MATERIALS LETTERS (2019)

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Article Biotechnology & Applied Microbiology

Toward a new generation of smart skins

Takao Someya et al.

NATURE BIOTECHNOLOGY (2019)

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Article Multidisciplinary Sciences

Development of wirelessly-powered, extracranial brain activator (ECBA) in a large animal model for the future non-invasive human neuromodulation

Hyungwoo Lee et al.

SCIENTIFIC REPORTS (2019)

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Article Chemistry, Multidisciplinary

The Future of Cardiovascular Stents: Bioresorbable and Integrated Biosensor Technology

Daniel Hoare et al.

ADVANCED SCIENCE (2019)

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Article Engineering, Biomedical

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Wubin Bai et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Article Chemistry, Physical

β-Phase Cu-Phthalocyanine/Acrylonitrile Butadiene Styrene Terpolymer Nanocomposite Film Technology for Organoelectronic Applications

RaviPrakash Magisetty et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2019)

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Review Chemistry, Multidisciplinary

Organic Synapses for Neuromorphic Electronics: From Brain-Inspired Computing to Sensorimotor Nervetronics

Yeongjun Lee et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Review Chemistry, Multidisciplinary

Wearable and Implantable Triboelectric Nanogenerators

Zhuo Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Cardiac & Cardiovascular Systems

Next-generation pacemakers: from small devices to biological pacemakers

Eugenio Cingolani et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Article Chemistry, Multidisciplinary

Direct Electrical Neurostimulation with Organic Pigment Photocapacitors

David Rand et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Methylxanthine Drug Monitoring with Wearable Sweat Sensors

Li-Chia Tai et al.

ADVANCED MATERIALS (2018)

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Article Biophysics

A silicon-based neural probe with densely-packed low-impedance titanium nitride microelectrodes for ultrahigh-resolution in vivo recordings

Richard Fiath et al.

BIOSENSORS & BIOELECTRONICS (2018)

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Article Biochemical Research Methods

Opto-electro-thermal optimization of photonic probes for optogenetic neural stimulation

Na Dong et al.

JOURNAL OF BIOPHOTONICS (2018)

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Review Clinical Neurology

Electrical Stimulation Mapping of the Brain: Basic Principles and Emerging Alternatives

Anthony L. Ritaccio et al.

JOURNAL OF CLINICAL NEUROPHYSIOLOGY (2018)

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Article Behavioral Sciences

Long-term Sustained Cognitive Benefits of Vagus Nerve Stimulation in Refractory Depression

Veronique Desbeaumes Jodoin et al.

JOURNAL OF ECT (2018)

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Article Multidisciplinary Sciences

State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures

Thierry Nieus et al.

SCIENTIFIC REPORTS (2018)

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Article Chemistry, Analytical

Wearable and Implantable Sensors for Biomedical Applications

Hatice Ceylan Koydemir et al.

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 11 (2018)

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Review Engineering, Electrical & Electronic

Magnetodielectric Microwave Radiation Absorbent Materials and Their Polymer Composites

Raviprakash Magisetty et al.

JOURNAL OF ELECTRONIC MATERIALS (2018)

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Article Multidisciplinary Sciences

Single-neuronal cell culture and monitoring platform using a fully transparent microfluidic DEP device

Hyungsoo Kim et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Fully integrated silicon probes for high-density recording of neural activity

James J. Jun et al.

NATURE (2017)

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Article Chemistry, Analytical

Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites

Bogdan C. Raducanu et al.

SENSORS (2017)

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Article Computer Science, Hardware & Architecture

A Thermal Energy Harvesting Power Supply With an Internal Startup Circuit for Pacemakers

Mohammadreza Ashraf et al.

IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS (2016)

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Review Immunology

Vagal Modulation of the Inflammatory Response in Sepsis

Da-Wei Wang et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

Frieda A. Koopman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Chemistry, Analytical

Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate

Suk Won Jung et al.

SENSORS (2016)

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Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

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Article Cardiac & Cardiovascular Systems

The first batteryless, solar-powered cardiac pacemaker

Andreas Haeberlin et al.

HEART RHYTHM (2015)

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Review Chemistry, Multidisciplinary

Three-dimensional micro/nanoscale architectures: fabrication and applications

Quan Xu et al.

NANOSCALE (2015)

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Article Biochemistry & Molecular Biology

Photovoltaic restoration of sight with high visual acuity

Henri Lorach et al.

NATURE MEDICINE (2015)

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Review Anesthesiology

Neurostimulation for Treatment of Migraine and Cluster Headache

Todd J. Schwedt et al.

PAIN MEDICINE (2015)

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Review Neurosciences

Retinal prostheses: progress toward the next generation implants

Diego Ghezzi

FRONTIERS IN NEUROSCIENCE (2015)

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Review Engineering, Biomedical

Optical Neural Interfaces

Melissa R. Warden et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16 (2014)

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Review Engineering, Biomedical

Energy harvesting for the implantable biomedical devices: issues and challenges

Mahammad A. Hannan et al.

BIOMEDICAL ENGINEERING ONLINE (2014)

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Article Engineering, Electrical & Electronic

Flexible Implantable Microtemperature Sensor Fabricated on Polymer Capillary by Programmable UV Lithography With Multilayer Alignment for Biomedical Applications

Zhuoqing Yang et al.

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS (2014)

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Article Multidisciplinary Sciences

First-in-Human Trial of a Novel Suprachoroidal Retinal Prosthesis

Lauren N. Ayton et al.

PLOS ONE (2014)

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Article Chemistry, Multidisciplinary

Nanotools for Neuroscience and Brain Activity Mapping

A. Paul Alivisatos et al.

ACS NANO (2013)

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Article Cell Biology

Fighting Blindness with Microelectronics

Eberhart Zrenner

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Optics

Photovoltaic retinal prosthesis with high pixel density

Keith Mathieson et al.

NATURE PHOTONICS (2012)

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Article Polymer Science

Fabrication and Packaging of Flexible Polymeric Microantennae for in Vivo Magnetic Resonance Imaging

Magdalena Couty et al.

POLYMERS (2012)

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Article Chemistry, Multidisciplinary

Tapering Control of Si Nanowires Grown from SiCl4 at Reduced Pressure

Sergiy Krylyuk et al.

ACS NANO (2011)

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Review Radiology, Nuclear Medicine & Medical Imaging

MRI of Patients With Cardiac Pacemakers: A Review of the Medical Literature

Joseph F. Zikria et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2011)

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Article Cardiac & Cardiovascular Systems

Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure

Gaetano M. De Ferrari et al.

EUROPEAN HEART JOURNAL (2011)

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Article Engineering, Biomedical

A Hermetic Wireless Subretinal Neurostimulator for Vision Prostheses

Shawn K. Kelly et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2011)

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Article Clinical Neurology

Efficacy of Vagus Nerve Stimulation for Epilepsy by Patient Age, Epilepsy Duration, and Seizure Type

Dario J. Englot et al.

NEUROSURGERY CLINICS OF NORTH AMERICA (2011)

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Article Anesthesiology

Societal Costs of Prescription Opioid Abuse, Dependence, and Misuse in the United States

Howard G. Birnbaum et al.

PAIN MEDICINE (2011)

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Article Biology

Subretinal electronic chips allow blind patients to read letters and combine them to words

Eberhart Zrenner et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

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Article Ophthalmology

Testing of Semichronically Implanted Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation in Patients with Retinitis Pigmentosa

Takashi Fujikado et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

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Article Clinical Neurology

Impaired consciousness in temporal lobe seizures: role of cortical slow activity

Dario J. Englot et al.

BRAIN (2010)

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Review Biochemistry & Molecular Biology

Microbattery Technologies for Miniaturized Implantable Medical Devices

M. Nathan

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)

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Article Engineering, Electrical & Electronic

Switch-Matrix-Based High-Density Microelectrode Array in CMOS Technology

Urs Frey et al.

IEEE JOURNAL OF SOLID-STATE CIRCUITS (2010)

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Review Neurosciences

Neural Syntax: Cell Assemblies, Synapsembles, and Readers

Gyoergy Buzsaki

NEURON (2010)

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Article Electrochemistry

Characterization of an Elastically Stretchable Microelectrode Array and Its Application to Neural Field Potential Recordings

O. Graudejus et al.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2009)

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Article Ophthalmology

Development of Microelectrode Arrays for Artificial Retinal Implants Using Liquid Crystal Polymers

Seung Woo Lee et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Performance of a miniature high-temperature superconducting (HTS) surface coil for in vivo microimaging of the mouse in a standard 1.5T clinical whole-body scanner

Marie Poirier-Quinot et al.

MAGNETIC RESONANCE IN MEDICINE (2008)

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Article Multidisciplinary Sciences

Inflammation and metabolic disorders

Goekhan S. Hotamisligil

NATURE (2006)

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Review Cardiac & Cardiovascular Systems

Frequency and causes of implantable cardioverter-defibrillator therapies: Is device therapy proarrhythmic?

JJ Germano et al.

AMERICAN JOURNAL OF CARDIOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Heart failure devices - Implantable cardioverter-defibrillators and biventricular pacing therapy

A Kadish et al.

CIRCULATION (2005)

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Review Behavioral Sciences

Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects

DA Groves et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2005)

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Article Engineering, Biomedical

Creating a meaningful visual perception in blind volunteers by optic nerve stimulation

M. E. Brelen et al.

JOURNAL OF NEURAL ENGINEERING (2005)

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Article Biochemistry & Molecular Biology

Microsensors and microbiosensors for retinal implants

DD Zhou et al.

FRONTIERS IN BIOSCIENCE (2005)

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Article Engineering, Electrical & Electronic

A 128x128 CMOS biosensor array for extracellular recording of neural activity

B Eversmann et al.

IEEE JOURNAL OF SOLID-STATE CIRCUITS (2003)

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Review Neurosciences

Mechanisms, challenges and opportunities in stroke

EH Lo et al.

NATURE REVIEWS NEUROSCIENCE (2003)

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Article Neurosciences

Neuronal substrates of sensory gating within the human brain

T Grunwald et al.

BIOLOGICAL PSYCHIATRY (2003)

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Review Clinical Neurology

Vagus-nerve stimulation for the treatment of epilepsy

E Ben-Menachem

LANCET NEUROLOGY (2002)

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Article Neurosciences

Vagus nerve stimulation (VNS™) for treatment-resistant depression:: Efficacy, side effects, and predictors of outcome

HA Sackeim et al.

NEUROPSYCHOPHARMACOLOGY (2001)

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Article Engineering, Biomedical

CMOS neurostimulation ASIC with 100 channels, scaleable output, and bidirectional radio-frequency telemetry

GJ Suaning et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2001)

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Article Engineering, Electrical & Electronic

A neuro-stimulus chip with telemetry unit for retinal prosthetic device

WT Liu et al.

IEEE JOURNAL OF SOLID-STATE CIRCUITS (2000)

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Article Engineering, Biomedical

Artificial vision for the blind by connecting a television camera to the visual cortex

WH Dobelle

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