Journal
JOURNAL OF SPORT AND HEALTH SCIENCE
Volume 11, Issue 6, Pages 708-715Publisher
SHANGHAI UNIV SPORT
DOI: 10.1016/j.jshs.2022.01.004
Keywords
Air pollution; Cohort study; Hypertension; Particulate matter; Physical activity
Funding
- National Key Research and Development Program of China [2018YFE0115300, 2017YFC0211703]
- National Natural Science Foundation of China [91643208, 82073658, 91843302]
- Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2021-I2M-1-010, 2017-I2M-1-004, 2019-I2M-2-003]
- China Medical Board [15-220]
- National Institute of Environmental Health Sciences of the National Institutes of Health [1R01ES032140]
- Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancers, Chinese Academy of Medical Sciences [2019RU038]
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This study found an interaction between the benefits of regular physical activity and exposure to air pollution in highly polluted regions on hypertension risk. Regular physical activity was associated with a reduced risk of hypertension only among participants with low PM2.5 exposure.
Background: The trade-off between the benefits of regular physical activity (PA) and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear. This study aimed to examine whether ambient fine particulate matter (PM2.5) exposure modified the impacts of PA volume and intensity on hypertension risk.Methods: We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project. PA volume and intensity were assessed by questionnaire, and high-resolution (1 km x1 km) PM2.5 estimates were generated using a satellite-based model.Results: During 413,516 person-years of follow-up, 12,100 incident hypertension cases were identified. PM2.5 significantly modified the relation-ship between PA and hypertension incidence (pinteraction < 0.001). Increased PA volume was negatively associated with incident hypertension in the low PM2.5 stratum (<59.8 mg/m3, ptrend < 0.001), with a hazard ratio of 0.81 (95% confidence interval (95%CI): 0.74-0.88) when comparing the fourth with the first quartile of PA volume. However, the health benefits were not observed in the high PM2.5 stratum (>= 59.8 mg/m3, ptrend = 0.370). Moreover, compared with light PA intensity, vigorous intensity was related to a 20% (95%CI: 9%-29%) decreased risk of hyper-tension for participants exposed to low PM2.5, but a 17% (95%CI: 4%-33%) increased risk for those with high PM2.5 levels.Conclusion: PA was associated with a reduced risk of hypertension only among participants with low PM2.5 exposure. Our findings recom-mended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.
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