Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-022-01292-1
Keywords
Sunscreens; Metal-organic frameworks; UV; Diffuse-reflectance; ZIF-8
Funding
- National Natural Science foundation of China [31971321, 81801815, 32001007, 31901002]
- Natural Science Foundation of Guangdong Province [2020A1515010826]
- Guangzhou Science, Technology and Innovation Commission [202002030498]
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The study found that ZIF-8 could potentially serve as a safe and effective substitute for sunscreens, with a wide range of applications. Metal-organic frameworks may also be a novel source for the development of more effective and safe UV filters.
Background: UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel UV filters with high safety and efficacy are urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for UV filter development, due to their tunable optical, electrical, and photoelectric properties by precise controlled synthesis. Results: Herein, four zinc-based MOFs with various bandgap energies were chose to investigate their optical behaviors and evaluate their possibility as sunscreens. Zeolitic imidazolate framework-8 (ZIF-8) was found to possess the highest and widest UV reflectance, thereby protecting against sunburn and DNA damage on mouse skin and even achieving a comparable or higher anti-UV efficacy relative to the commercially available UV filters, TiO2 or ZnO, on pig skin, a model that correlates well with human skin. Also, ZIF-8 exerted appealing characteristics for topical skin use with low radical production, low skin penetration, low toxicity, high transparency, and high stability. Conclusion: These results confirmed ZIF-8 could potentially be a safe and effective sunscreen surrogate for human, and MOFs could be a novel source to develop more effective and safe UV filters.
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