Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-021-01080-3
Keywords
Photothermal therapy; Selective killing; Targeted enrichment; Self-regulating
Funding
- National Natural Science Foundation of China [81774125, 81973671]
- Natural Science Foundation of Shandong Province [ZR2019BB071]
- major innovation and technology engineering project of Shandong Province [2019JZZY011106]
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Photothermal therapy (PTT) is a promising approach in cancer treatment, but challenges such as accurate laser exposure and potential side effects need to be addressed. Enhancing the selectivity of PTT involves increasing the accumulation of photothermal agents at tumor sites and giving them self-regulating photothermal conversion functions.
Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the systemic distribution of photothermal agents (PTAs) in the body and inaccurate laser exposure during treatment. To further improve the survival rate of cancer patients and reduce possible side effects on other parts of the body, it is still necessary to explore PTAs with high selectivity and precise treatment. In this review, we summarized strategies to improve the treatment selectivity of PTT, such as increasing the accumulation of PTAs at tumor sites and endowing PTAs with a self-regulating photothermal conversion function. The views and challenges of selective PTT were discussed, especially the prospects and challenges of their clinical applications.
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