Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 10, Issue 6, Pages 899-908Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb02601a
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Funding
- National Natural Science Foundation of China [21921003]
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Water-soluble three-dimensional supramolecular-organic frameworks and temoporfin can self-assemble into uniform nanoparticles, which exhibit biocompatibility and improved anti-tumor activity.
Water-soluble three-dimensional supramolecular-organic frameworks (SOFs) and temoporfin (mTHPC) are discovered to form uniform self-assembled nanoparticles. These nanoparticles demonstrate an improved O-1(2) generation efficiency due to the reduced aggregation-caused quenching effect. SOFs and self-assembled nanoparticles are biocompatible. Self-assembled nanoparticles display an improved photo cytotoxicity toward four types of human cancer cells. The tumor model in mice shows that self-assembled nanoparticles could efficiently suppress tumor growth in vivo.
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