Journal
JOURNAL OF CANCER
Volume 13, Issue 2, Pages 450-464Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.68264
Keywords
Cholangiocarcinoma; Insight; Treatment
Categories
Funding
- Youth Talent of Hunan [2020RC3066]
- Hunan Natural Science Fund for Excellent Young Scholars [2021JJ20003]
- Hunan Provincial Natural Science Foundation of China [2020JJ5610]
- China Postdoctoral Science Foundation [2020M68115/2021T140197]
- Hunan Provincial Development and Reform Commission Project [2019FGW26]
- Clinical Medical TechnologyInnovation Guidance Project of Hunan Provincial Science and Technology Department [2020SK50918/2020SK50915/2020SK0914]
- Project of Hunan Provincial Health Commission [202104010997]
- Education fund item of Hunan Province [20B380]
- Chen Xiao-Ping Foundation for Development of Science and Technology of Hubei Province [CXPJJH12000001-2020322]
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Cholangiocarcinoma is a rare but highly malignant tumor with increasing incidence and death rate. Treatment options include surgery, radiotherapy, and chemotherapy, with targeted therapy and immunotherapy showing potential. Clinical trials for cholangiocarcinoma are underway.
Cholangiocarcinoma (CCA) is a relatively rare malignant tumor originating from the bile duct epithelial cells, and it is one of the malignant tumors with fast growth in incidence and death rate in recent years. CCA carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. Currently, surgery is the only possible curative treatment, radiotherapy and chemotherapy also play an important role in slowing down disease progression, while targeted therapy and immunotherapy are changing with each passing day and their combined effect may have great potential for the treatment of CCA; Clinical trials of various treatment options for CCA are also being conducted. This article reviews the different treatment options for CCA and explores the adjuvant treatment for it from a new perspective. In the future, the goal of treatment should be multiple and combined for different CCA patients to achieve individualized programs and improve overall survival.
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