Early Growth Response-1, an Integrative Sensor in Cardiovascular and Inflammatory Disease

Early growth response-1 (Egr-1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate-early gene plays in a range of cardiovascular and inflammatory disorders. Egr-1 can amplify pathologic signals from the extracellular environment by serving as a molecular conduit in the inducible expression of proliferative, migratory and proinflammatory genes driving disease progression. Strategies targeting Egr-1 may provide therapeutic benefit in cardiovascular and inflammatory disorders.

Automated summary

Egr-1 serves as a master regulator and transcriptional sensor in vascular dysfunction and disease, amplifying pathologic signals by inducing the expression of proliferative, migratory, and proinflammatory genes. Targeting Egr-1 may offer therapeutic benefits in cardiovascular and inflammatory disorders.