Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume 220, Issue -, Pages 61-64Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2016.06.185
Keywords
MicroRNA; Mechanism; Heart failure
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Funding
- National Natural Science Foundation of China [81270229]
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Heart failure is the end stage of most cardiac diseases and also an important cardiovascular disease. Ventricular remodeling, a complicated pathophysiological process involving multiple molecular pathways, is a crucial mechanism for the occurrence and development of heart failure. A microRNA (miRNA) is a highly conservative noncoding molecule containing 18-25 nucleotides. miRNA is different from other RNAs. It mainly serves as an endogenous gene-regulating factor, and is a member of the complex regulatory network. It induces gene repression of target transcripts by affecting mRNA at the post-transcriptional level Vasudevan et al. (2007). This study aimed at determining the mechanism of miRNA action in heart failure. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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