Updated HIV-1 Consensus Sequences Change but Stay Within Similar Distance From Worldwide Samples

Article Biochemical Research Methods

SARS2020: an integrated platform for identification of novel coronavirus by a consensus sequence-function model

Dachuan Zhang et al.

Summary: The research team created a comprehensive scientific resource called SARS2020, which integrates coronavirus-related research, genomic sequences, and results of anti-viral drug trials. By establishing a consensus sequence-catalytic function model, it was found that the novel coronavirus encodes the same proteinase as the severe acute respiratory syndrome virus, enabling rapid identification of agents responsible for future epidemics.

BIOINFORMATICS (2021)

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Article Biophysics

Learning the local landscape of protein structures with convolutional neural networks

Anastasiya Kulikova et al.

Summary: The study investigates the use of 3D convolutional neural networks for predicting protein structures from amino acid sequences. The network can accurately predict wild type with good confidence levels, but has less accuracy in predicting consensus, primarily driven by whether or not the consensus matches the wild type. High-confidence mis-predictions of the wild type may indicate sites that are primed for mutation and could be targets for protein engineering.

JOURNAL OF BIOLOGICAL PHYSICS (2021)

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Article Microbiology

Historical Perspective on the Discovery of the Quasispecies Concept

Esteban Domingo et al.

Summary: Viral quasispecies are dynamic distributions of nonidentical but closely related mutant and recombinant viral genomes that undergo genetic variation, competition, and selection. The concept originated from a model for the origin of life and experimental evidence from bacteriophage clones. Quasispecies dynamics reveal complexities in viral population behavior with implications for disease mechanisms and control strategies.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

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Article Genetics & Heredity