Journal
FRONTIERS IN MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.756136
Keywords
type VI secretion system; effectors; metal ions; transport; regulation
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Funding
- National Key R&D Program of China [2018YFA0901200]
- National Natural Science Foundation of China [31725003, 31670053]
- Comprehensive treatment of Xiaokongtong Gully Project: Research and application of in situ greening and soil consolidation technology [QYLF-JSYY-2020029]
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The type VI secretion system (T6SS) in gram-negative bacteria has multiple functions, including the newly discovered function of metal ion transport. The review provides a summary of identified T6SS functions and discusses the features and regulation of metal ion transport mediated by T6SS.
The type VI secretion system (T6SS) is a transmembrane protein nanomachine employed by many gram-negative bacteria to directly translocate effectors into adjacent cells or the extracellular milieu, showing multiple functions in both interbacterial competition and bacteria-host interactions. Metal ion transport is a newly discovered T6SS function. This review summarizes the identified T6SS functions and highlights the features of metal ion transport mediated by T6SS and discusses its regulation.
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