Journal
FRONTIERS IN MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.738401
Keywords
microbiome-gut-brain axis (MGBA); microbiota manipulation; substance-related disorders; gut microbiota; fecal microbiome transplantation
Categories
Funding
- Hunan Province Natural Science Foundation Project [2021JJ40894]
- Scientific Research Project of Hunan Provincial Health Commission [202103090528]
- Changsha Natural Science Foundation Project [kq2014239]
- Central South University Undergraduate Research and Innovation (URI) Program [XCX20190547]
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Substance addiction is a complex worldwide public health issue that endangers both individuals and society, while the gut microbiome may play a crucial role in the pathogenesis of substance-related disorders.
Substance addiction is a complex worldwide public health problem. It endangers both personal life and social stability, causing great loss on economy. Substance-related disorder is considered to be a complicated chronic brain disorder. It resulted from interactions among pharmacological properties of addictive substances, individual susceptibility, and social-environmental factors. Unfortunately, there is still no ideal treatment for this disorder. Recent lines of evidence suggest that gut microbiome may play an important role in the pathogenesis of neuropsychiatric disorders, including substance-related disorders. This review summarizes the research on the relationship between gut microbiome and substance-related disorders, including different types of substance, different individual susceptibility, and the occurrence and development of substance-induced mental disorders. We also discuss the potentiation of gut microbiome in the treatment of substance-related disorders, especially in the treatment of substance-induced mental disorders and manipulation on individuals' responsiveness to addictive substances.
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