Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus

Type I interferon (IFN-I) mediated innate immunity serves as the first line of host defense against viral infection, ranging from IFN-I production upon viral detection, IFN-I triggered signaling pathway that induces antiviral gene transcription the antiviral effects of IFN-I induced gene products. During coevolution, herpesviruses have developed multiple countermeasures to inhibit the various steps involved to evade the IFN response. This mini-review focuses on the strategies used by the alphaherpesvirus Pseudorabies virus (PRV) to antagonize IFN-I mediated innate immunity, with a particular emphasis on the mechanisms inhibiting IFN-I induced gene transcription through the JAK-STAT pathway. The knowledge obtained from PRV enriches the current understanding of the alphaherpesviral immune evasion mechanisms and provides insight into the vaccine development for PRV control.

Automated summary

This review highlights the importance of IFN-I mediated innate immunity in defense against viral infection, focusing on the strategies employed by the alphaherpesvirus Pseudorabies virus (PRV) to counteract IFN-I mediated immunity, particularly through inhibition of IFN-I induced gene transcription via the JAK-STAT pathway. Knowledge gained from PRV contributes to understanding alphaherpesviral immune evasion mechanisms and aids in vaccine development for PRV control.