4.8 Article

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19

Juan Gomez et al.

Summary: The IFITM3 rs12252 C allele is significantly associated with an increased risk of COVID-19 hospitalization in our Caucasian population, with a higher frequency among patients in the intensive care unit, but the extent of the association is lower than reported in the Chinese population.

CYTOKINE (2021)

Article Multidisciplinary Sciences

Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira et al.

Summary: In critically ill patients with COVID-19, host genetic variants associated with antiviral defense mechanisms and inflammatory organ damage were identified through a genome-wide association study. These genetic signals provide potential targets for therapeutic development and repurposing of existing drugs. Large-scale randomized clinical trials will be essential to confirm the effectiveness of targeted treatment strategies.

NATURE (2021)

Article Immunology

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Ioanna-Evdokia Galani et al.

Summary: Andreakos and colleagues conducted a study comparing patients with COVID-19 and influenza, finding that COVID-19 patients exhibited a dysregulated interferon response with diminished and delayed interferon production compared to flu patients. In COVID-19 patients, pro-inflammatory cytokines were produced before interferons and persisted longer, leading to worsened clinical outcomes.

NATURE IMMUNOLOGY (2021)

Article Cell Biology

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Xin Yin et al.

Summary: Recent studies show that cellular responses to SARS-CoV-2 infection may influence disease severity, with MDA5 and LGP2 primarily regulating IFN induction in lung epithelial cells. Further analysis revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing, and transcription factors IRF3, IRF5, and NF-kappa B/p65 play key roles in regulating the IFN response during SARS-CoV-2 infection. These findings provide valuable insights into the molecular mechanisms of innate immune recognition and signaling response to SARS-CoV-2.

CELL REPORTS (2021)

Article Virology

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Antoine Rebendenne et al.

Summary: The study found that in lung cells, despite producing high levels of IFNs in response to SARS-CoV-2 infection, the IFN response was unable to control viral replication, contrary to what was observed in intestinal epithelial cells. The ambiguous interplay between viral replication and the timing of IFN responses needs to be further understood for guiding future therapeutic interventions.

JOURNAL OF VIROLOGY (2021)

Article Medicine, General & Internal

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Anthony C. Gordon et al.

Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Critical Care Medicine

Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan A Retrospective Observational Study

Yingzhen Du et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Critical Care Medicine

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

Jesus Villar et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Medicine, General & Internal

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Multidisciplinary Sciences

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Kangpeng Xiao et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Jonas Schulte-Schrepping et al.

Article Biochemistry & Molecular Biology

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

Aaron J. Wilk et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

David Ellinghaus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis

Jonathan A. C. Sterne et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

Article Immunology

Natural killer cell immunotypes related to COVID-19 disease severity

Christopher Maucourant et al.

SCIENCE IMMUNOLOGY (2020)

Article Critical Care Medicine

SARS-CoV-2 analysis on environmental surfaces collected in an intensive care unit: keeping Ernest Shackleton's spirit

Dolores Escudero et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2020)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Article Critical Care Medicine

Hospital Incidence and Outcomes of the Acute Respiratory Distress Syndrome Using the Kigali Modification of the Berlin Definition

Elisabeth D. Riviello et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

Review Endocrinology & Metabolism

Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression

Benjamin M. Looney et al.

CURRENT DIABETES REPORTS (2015)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemistry & Molecular Biology

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

Ian C. Berke et al.

EMBO JOURNAL (2012)

Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

Review Mathematical & Computational Biology

Simultaneous inference in general parametric models

Torsten Hothorn et al.

BIOMETRICAL JOURNAL (2008)