Journal
ELIFE
Volume 10, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.68795
Keywords
hippocampus; prefrontal cortex; cycle skipping; memory; theta sequences
Categories
Funding
- Canadian Institutes of Health Research [367017, 377074]
- Natural Sciences and Engineering Research Council of Canada [74105]
- Canada Research Chairs
- National Institute of Mental Health [R01 MH120073, R01 MH060013]
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The passage discusses the connection between envisioning the future and remembering the past, explaining the roles of the prefrontal cortex and hippocampus in memory and future planning, as well as how brain regions support the temporal organization of information.
Envisioning the future is intuitively linked to our ability to remember the past. Within the memory system, substantial work has demonstrated the involvement of the prefrontal cortex and the hippocampus in representing the past and present. Recent data shows that both the prefrontal cortex and the hippocampus encode future trajectories, which are segregated in time by alternating cycles of the theta rhythm. Here, we discuss how information is temporally organized by these brain regions supported by the medial septum, nucleus reuniens, and parahippocampal regions. Finally, we highlight a brain circuit that we predict is essential for the temporal segregation of future scenarios.
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