Journal
CLINICAL EPIGENETICS
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13148-021-01173-8
Keywords
Epigenetics; Undernutrition; Stunting; Histone acetylation; One-carbon metabolism
Categories
Funding
- Bill and Melinda Gates Foundation [OPP1017093]
- National Institutes of Health [R01 AI043596]
- Wagner Fellowship
- Bill and Melinda Gates Foundation [OPP1017093] Funding Source: Bill and Melinda Gates Foundation
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This study explores how epigenetic changes in children's DNA can impact their growth and development, leading to stunting. Results show that children at risk of stunting exhibit elevated levels of H3K27ac, related to immune system activation, while overt stunting is associated with reduced H3K27ac levels, indicating metabolic changes and downregulation of immune pathways. The findings suggest that alterations in one-carbon metabolism may play a role in the development of stunting in children.
Background: Stunting is a condition in which a child does not reach their full growth potential due to chronic undernutrition. It arises during the first 2 years of a child's life and is associated with developmental deficiencies and life-long health problems. Current interventions provide some benefit, but new approaches to prevention and treatment grounded in a molecular understanding of stunting are needed. Epigenetic analyses are critical as they can provide insight into how signals from a poor environment lead to changes in cell function. Results: Here we profiled histone H3 acetylation on lysine 27 (H3K27ac) in peripheral blood mononuclear cells (PBMCs) of 18-week-old (n = 14) and 1-year-old children (n = 22) living in an urban slum in Dhaka, Bangladesh. We show that 18-week-old children destined to become stunted have elevated levels of H3K27ac overall, functional analysis of which indicates activation of the immune system and stress response pathways as a primary response to a poor environment with high pathogen load. Conversely, overt stunting at 1-year-of age is associated with globally reduced H3K27ac that is indicative of metabolic rewiring and downregulation of the immune system and DNA repair pathways that are likely secondary responses to chronic exposure to a poor environment with limited nutrients. Among processes altered in 1-year-old children, we identified one-carbon metabolism, the significance of which is supported by integrative analysis with results from histone H3 trimethylation on lysine 4 (H3K4me3). Together, these results suggest altered one-carbon metabolism in this population of stunted children. Conclusions: The epigenomes of stunted children undergo two global changes in H3K27ac within their first year of life, which are associated with probable initial hyperactive immune responses followed by reduced metabolic capacity. Limitation of one-carbon metabolites may play a key role in the development of stunting.
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