Journal
CHINESE MEDICINE
Volume 16, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13020-021-00554-8
Keywords
Mineral excipients; Processing; Traditional Chinese medicine (TCM); Components; Pharmacodynamics; Mechanism
Funding
- National Natural Science Foundation of China [81703675]
- China Postdoctoral Science Foundation [2021M692398]
- Natural Science Foundation of Liaoning Province [2019-ZD-0631, 2019-ZD-0914]
- Dalian Municipal Medical Research Foundation [20Z12005]
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Mineral excipients play important roles in the pretreatment process of traditional Chinese medicines, but the lack of holistic understanding of their effects hinders their application and development. This review explores several mineral excipients, revealing their processing significance on traditional Chinese medicines through components, pharmacodynamics, and mechanism aspects.
Traditional Chinese medicines are an important class of natural products mainly derives from animals, plants and minerals, most of which need to be improved and processed before clinical use due to their own hard texture, impurities or toxicity. As an important part of solid excipients, mineral excipients that contain some metal elements play indispensable and unique roles in the pretreatment process of traditional Chinese medicine. However, deficiency of holistic understanding of the effect of mineral excipients hinders their application and development. This article reviews several mineral excipients including alumen, talci pulvis, soil, soda lime, halloysitum rubrum and cinnabaris systemically. Their processing significance on traditional Chinese medicines were revealed from components, pharmacodynamics and mechanism aspects. Furthermore, prospect and problems including processing technologies, quality standards of mineral excipients and processing mechanism were put forward. This review supply comprehensive information for better and scientific usage of mineral excipients in processing traditional Chinese medicines.
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