Journal
CHEMISTRYOPEN
Volume 10, Issue 12, Pages 1186-1196Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.202100221
Keywords
antibacterial activity; fucoidan; Hantzsch reaction; magnetic graphene oxide; polymer-coated nanoparticles
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Polymer-coated magnetic nanoparticles, specifically BaFe12O19@GO@Fu, show exceptional catalytic activity in the synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives with high turnover numbers and frequencies. Additionally, BaFe12O19@GO@Fu exhibits antibacterial activity against Staphylococcus aureus, making it a promising material for various applications.
Polymer-coated magnetic nanoparticles are emerging as a useful tool for a variety of applications, including catalysis. In the present study, fucoidan-coated magnetic graphene oxide was synthesized using a natural sulfated polysaccharide. The prepared BaFe12O19@GO@Fu (Fu=fucoidan, GO=graphene oxide) was characterized using Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) analysis, vibrating sample magnetometry (VSM), thermogravimetric analysis (TGA), Raman spectroscopy, and X-ray diffraction (XRD). The catalytic proficiency of BaFe12O19@GO@Fu was investigated in the synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives. Excellent turnover numbers (TON) and turnover frequencies (TOF) (6330 and 25320 h(-1)) testify to the high efficiency of the catalyst. Moreover, the antimicrobial activity of BaFe12O19@GO@Fu was evaluated against Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus) through the Agar well diffusion method, indicating that BaFe12O19@GO@Fu has antibacterial activity against S. aureus.
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