Journal
BIOMATERIALS SCIENCE
Volume 10, Issue 6, Pages 1486-1497Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm01848e
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Funding
- Special Project on Development of National Key Scientific Instruments and Equipment of China [2011YQ03013403]
- National Natural Science Foundation of China [81572555]
- National Natural Science Youth Foundation of China [81600407]
- Suzhou Medical Apparatus and New Medicine Fund [ZXY201440]
- Fundamental Research Funds for the Central Universities
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In this study, a physicochemically double-network crosslinked hydrogel matrix was prepared to solve the challenge of robust adhesion capability of hydrogel adhesives in wet environments. The hydrogel exhibited persistent adhesion and excellent hemostatic performance, making it potentially applicable in medical adhesives.
To date, the robust and durable adhesion capability of hydrogel adhesives in wet environments remains a huge challenge. Herein, a physicochemically double-network crosslinked hydrogel matrix was prepared by mixing acrylic acid (AAc), chitosan (CS) and tannic acid (TA) as the main components and the subsequent in situ polymerization of AAc. The abundant reactive sites on the surface of the hydrogel matrix facilitate rapid, strong and repeatable adhesion to different surfaces of engineering solids and biological tissues in an aquatic environment. The formation of amide covalent bonds resulting from the addition of the bridging agent further expands the long-term application of the hydrogel in tissue repair, and the constructed hydrogel-tissue adhesive interface still has robust adhesion energy after soaking in a physiological environment for up to one month. Moreover, the hydrogel showed fantastic hemostatic performance due to its characteristics of platelet adhesion and high burst pressure. Overall, the persistent adhesion and excellent cytocompatibility of the hydrogel adhesive make it potentially applicable in medical adhesives.
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