N-Iodosuccinimide-promoted Regioselective Selenylation of 4H-Pyrido-[1,2-a]-pyrimidin-4-ones with Diselenides at Room Temperature

A novel and efficient approach for the regioselective selenylation of 4H-pyrido-[1,2-a]-pyrimidin-4-ones with diselenides at room temperature has been developed. This procedure is catalyzed by N-iodosuccinimide under metal-free conditions with a broad range of substrate scopes and affords C3 selenylation products in good to excellent yields. Furthermore, the sulfenylation with diphenyl disulfides and 4-methylbenzenethiol in this transformation is successful.

Automated summary

A novel and efficient method for regioselective selenylation of 4H-pyrido-[1,2-a]-pyrimidin-4-ones with diselenides at room temperature has been developed. The procedure is catalyzed by N-iodosuccinimide under metal-free conditions and provides good to excellent yields of C3 selenylation products across a broad range of substrates. Furthermore, sulfenylation with diphenyl disulfides and 4-methylbenzenethiol in this transformation is also successful.