Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 11, Pages 2911-2915Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100576
Keywords
Selenylation; 4H-pyrido[1; 2-a]pyrimidin-4-ones; diselenides; regioselectivity; metal-free
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Funding
- Foundation for Natural Science Foundation of Guangdong Province [2017A030313297]
- special funds of key disciplines construction from Guangdong and Zhongshan cooperating
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A novel and efficient method for regioselective selenylation of 4H-pyrido-[1,2-a]-pyrimidin-4-ones with diselenides at room temperature has been developed. The procedure is catalyzed by N-iodosuccinimide under metal-free conditions and provides good to excellent yields of C3 selenylation products across a broad range of substrates. Furthermore, sulfenylation with diphenyl disulfides and 4-methylbenzenethiol in this transformation is also successful.
A novel and efficient approach for the regioselective selenylation of 4H-pyrido-[1,2-a]-pyrimidin-4-ones with diselenides at room temperature has been developed. This procedure is catalyzed by N-iodosuccinimide under metal-free conditions with a broad range of substrate scopes and affords C3 selenylation products in good to excellent yields. Furthermore, the sulfenylation with diphenyl disulfides and 4-methylbenzenethiol in this transformation is successful.
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