Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 12, Pages 3370-3373Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100584
Keywords
Cascade cyclization; Flow synthesis; Metal-free; N-aryl 4-pyridone; Pyridone
Categories
Funding
- National Natural Science Foundation of China [21662046, 21202142]
- program for the application fundamental research of Yunnan Province [2018FB019]
- Program for Innovative Research Team (in science and technology) at the University of Yunnan Province
- National Innovation Training Program for College Students, Scientific and Technological Innovation Team for Green Catalysis and Energy Material in Yunnan Institutions of Higher Learning
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A practical synthetic approach to access N-aryl/N-alkyl 4-pyridones via a two-step continuous flow process has been developed, which can provide derivatives with a wider substrate scope and good to excellent yields.
In this report, a practical synthetic approach to access N-aryl/N-alkyl 4-pyridones via a two-step continuous flow process has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three-components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate under mild conditions, which can provide N-aryl/N-alkyl 4-pyridone derivatives with a wider substrate scope and good to excellent yields.
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