Synthesis of Acrylonitrile Derivatives via Visible Light-induced Coupling Reaction of Morita-Baylis-Hillman Adducts with Tertiary Amines and α-Trimethylsilyl Amines

Ru-catalyzed coupling reaction of Morita-Baylis-Hillman (MBH) adducts with tertiary amines and alpha-trimethylsilyl amines under visible light is disclosed. Compared with the reported MBH adducts with ester as withdrawing-electron groups, MBH adducts with cyano group in this paper show different chemical reaction characteristics. The universality of substrates has been extended. A series of structurally complementary acrylonitriles are obtained in satisfied yields under mild condition, which provides a good opportunity to discover new meaningful bioactive compounds.

Automated summary

The Ru-catalyzed coupling reaction of Morita-Baylis-Hillman (MBH) adducts with tertiary amines and alpha-trimethylsilyl amines under visible light showed different chemical reaction characteristics when compared to MBH adducts with ester groups as withdrawing-electron groups. The universality of substrates has been extended, allowing for the synthesis of structurally complementary acrylonitriles in satisfied yields under mild conditions and providing an opportunity to discover new meaningful bioactive compounds.