Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 10, Issue 1, Pages 530-540Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.1c07026
Keywords
hydroxylation; harvesting of solar energy; metal-free; gram-scale synthesis; recyclability of the catalyst
Categories
Funding
- BOF joint PhD grant
- Francqui Foundation
- FWO research grant
- Chinese Scholarship Council
- Swedish Energy Agency [50501-1]
- Hercules Fund from the Flemish Government
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In this study, a metal-free heterogeneous photocatalyst was developed for the direct hydroxylation of tertiary benzylic C(sp(3))-H bonds using oxygen as the key reagent. The gram-scale reaction was achieved with high product yield using direct solar energy. The high stability of the catalyst was proven through catalyst recycling and spectroscopic analyses, and a possible mechanism was proposed based on experimental evidence.
Direct hydroxylation via the functionalization of tertiary benzylic C(sp(3))-H bonds is of great significance for obtaining tertiary alcohols, which find wide applications in pharmaceuticals as well as in fine chemical industries. However, current synthetic procedures use toxic reagents, and therefore, the development of a sustainable strategy for the synthesis of tertiary benzylic alcohols is highly desirable. To solve this problem, herein, we report a metal-free heterogeneous photocatalyst to synthesize the hydroxylated products using oxygen as the key reagent. Various benzylic substrates were employed into our mild reaction conditions to afford the desirable products in good to excellent yields. More importantly, the gram-scale reaction was achieved via harvesting direct solar energy and exhibited high quantity of the product. The high stability of the catalyst was proved via recycling the catalyst and spectroscopic analyses. Finally, a possible mechanism was proposed based on electron paramagnetic resonance and other experimental evidence.
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